Details of the Target

General Information of Target

Target ID LDTP09801
Target Name Protein FAM168A (FAM168A)
Gene Name FAM168A
Gene ID 23201
Synonyms
KIAA0280; TCRP1; Protein FAM168A; Tongue cancer chemotherapy resistance-associated protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSSRLRVFDPHLERKDSAAALSDRELPLPTFDVPYFKYIDEEDEDDEWSSRSQSSTEDD
SVDSLLSDRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQ
ALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVL
DDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET
EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPN
DLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSL
FNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKF
IKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHK
AYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTN
QFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV
Target Bioclass
Other
Family
FAM168 family
Function
In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.
Uniprot ID
Q92567
Ensemble ID
ENST00000064778.8
HGNC ID
HGNC:28999

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y109(21.36)  LDD3495  [1]
DBIA
 Probe Info  		C75(1.07)  LDD0813  [2]
SF
 Probe Info  		N.A.  LDD0028  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C75(1.07)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C75(1.01)  LDD0824  [2]
 LDCM0237  AC12 HEK-293T C75(1.13)  LDD0835  [2]
 LDCM0259  AC14 HEK-293T C75(1.13)  LDD0857  [2]
 LDCM0270  AC15 HEK-293T C75(1.14)  LDD0868  [2]
 LDCM0285  AC25 HEK-293T C75(0.85)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C75(1.09)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C75(0.89)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C75(0.74)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C75(1.31)  LDD0887  [2]
 LDCM0291  AC30 HEK-293T C75(0.86)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C75(0.93)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C75(1.18)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C75(0.85)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C75(0.75)  LDD0893  [2]
 LDCM0308  AC46 HEK-293T C75(1.12)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C75(0.99)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C75(1.23)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C75(1.05)  LDD0909  [2]
 LDCM0313  AC50 HEK-293T C75(1.10)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C75(0.98)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C75(1.20)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C75(1.30)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C75(0.94)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C75(1.03)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C75(1.38)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C75(0.93)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C75(1.12)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C75(1.42)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C75(1.26)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C75(1.11)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C75(1.00)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C75(1.17)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C75(1.09)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C75(1.00)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C75(1.14)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C75(1.13)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C75(0.96)  LDD0929  [2]
 LDCM0334  AC7 HEK-293T C75(0.85)  LDD0932  [2]
 LDCM0345  AC8 HEK-293T C75(1.09)  LDD0943  [2]
 LDCM0248  AKOS034007472 HEK-293T C75(0.95)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C75(1.06)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C75(1.24)  LDD0873  [2]
 LDCM0370  CL101 HEK-293T C75(1.20)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C75(1.16)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C75(1.10)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C75(1.30)  LDD0971  [2]
 LDCM0382  CL112 HEK-293T C75(1.17)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C75(1.16)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C75(1.04)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C75(0.80)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C75(1.06)  LDD0984  [2]
 LDCM0392  CL121 HEK-293T C75(1.08)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C75(1.00)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C75(1.40)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C75(1.05)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C75(1.21)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C75(1.28)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C75(1.39)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C75(0.99)  LDD0997  [2]
 LDCM0453  CL61 HEK-293T C75(1.03)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C75(1.03)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C75(1.55)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C75(1.71)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C75(1.25)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C75(1.08)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C75(1.25)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C75(1.68)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C75(1.40)  LDD1059  [2]
 LDCM0463  CL70 HEK-293T C75(1.63)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C75(1.11)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C75(0.92)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C75(1.40)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C75(1.54)  LDD1065  [2]
 LDCM0468  Fragment33 HEK-293T C75(1.28)  LDD1066  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) AlkB family Q9NXW9
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
Ubiquitin thioesterase otulin (OTULIN) Peptidase C65 family Q96BN8
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) Ubiquitin-conjugating enzyme family Q13404
DCN1-like protein 1 (DCUN1D1) . Q96GG9
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9
Lysine-specific demethylase hairless (HR) . O43593
Ubiquitin thioesterase OTU1 (YOD1) . Q5VVQ6
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Other
Click To Hide/Show 41 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Ataxin-1-like (ATXN1L) ATXN1 family P0C7T5
Splicing factor 1 (SF1) BBP/SF1 family Q15637
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Proline-rich protein 20C (PRR20C) PRR20 family P86479
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Calcium-responsive transactivator (SS18L1) SS18 family O75177
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) Ubiquitin family; Eukaryotic ribosomal protein eL40 family P62987
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) Ubiquitin family; Eukaryotic ribosomal protein eS31 family P62979
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
YTH domain-containing family protein 1 (YTHDF1) YTHDF family Q9BYJ9
DAZ-associated protein 2 (DAZAP2) . Q15038
Disabled homolog 1 (DAB1) . O75553
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 42 (KLHL42) . Q9P2K6
Peflin (PEF1) . Q9UBV8
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
Protein TFG (TFG) . Q92734
RNA-binding protein with multiple splicing (RBPMS) . Q93062
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
Selenocysteine insertion sequence-binding protein 2 (SECISBP2) . Q96T21
Stromal membrane-associated protein 2 (SMAP2) . Q8WU79
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1
UBX domain-containing protein 6 (UBXN6) . Q9BZV1
UBX domain-containing protein 7 (UBXN7) . O94888
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004