Details of the Target

General Information of Target

Target ID LDTP09781
Target Name Y+L amino acid transporter 2 (SLC7A6)
Gene Name SLC7A6
Gene ID 9057
Synonyms
KIAA0245; Y+L amino acid transporter 2; Cationic amino acid transporter, y+ system; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYAQPVTNTKEVKWQKVLYERQPFPDNYVDRRFLEELRKNIHARKYQYWAVVFESSVVIQ
QLCSVCVFVVIWWYMDEGLLAPHWLLGTGLASSLIGYVLFDLIDGGEGRKKSGQTRWADL
KSALVFITFTYGFSPVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLN
MAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSAV
GGLLSISAVGAVLFALLLMSISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS
Target Bioclass
Transporter and channel
Family
Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Subcellular location
Cell membrane
Function
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1. Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration. May mediate transport of ornithine in retinal pigment epithelial (RPE) cells. May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte.
Uniprot ID
Q92536
Ensemble ID
ENST00000219343.11
HGNC ID
HGNC:11064

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C497(1.13)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C497(1.13)  LDD1507  [1]
 LDCM0259  AC14 HEK-293T C497(1.02)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C497(1.08)  LDD1515  [1]
 LDCM0281  AC21 HEK-293T C497(1.02)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C497(1.00)  LDD1521  [1]
 LDCM0285  AC25 HEK-293T C497(1.06)  LDD1524  [1]
 LDCM0289  AC29 HEK-293T C497(1.03)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C497(1.00)  LDD1530  [1]
 LDCM0294  AC33 HEK-293T C497(1.07)  LDD1533  [1]
 LDCM0298  AC37 HEK-293T C497(1.06)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C497(0.95)  LDD1538  [1]
 LDCM0303  AC41 HEK-293T C497(1.22)  LDD1542  [1]
 LDCM0307  AC45 HEK-293T C497(1.11)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C497(1.12)  LDD1547  [1]
 LDCM0311  AC49 HEK-293T C497(1.15)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C497(0.98)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C497(1.01)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C497(1.01)  LDD1556  [1]
 LDCM0320  AC57 HEK-293T C497(1.17)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C497(1.07)  LDD1562  [1]
 LDCM0325  AC61 HEK-293T C497(1.20)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C497(0.94)  LDD1565  [1]
 LDCM0248  AKOS034007472 HEK-293T C497(1.13)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C497(1.17)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C497(1.00)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C497(0.92)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C497(1.09)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C497(1.00)  LDD1574  [1]
 LDCM0373  CL104 HEK-293T C497(1.05)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C497(0.87)  LDD1578  [1]
 LDCM0377  CL108 HEK-293T C497(1.04)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C497(1.00)  LDD1582  [1]
 LDCM0382  CL112 HEK-293T C497(1.03)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C497(1.03)  LDD1587  [1]
 LDCM0386  CL116 HEK-293T C497(1.10)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C497(1.09)  LDD1591  [1]
 LDCM0391  CL120 HEK-293T C497(1.05)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C497(0.95)  LDD1596  [1]
 LDCM0395  CL124 HEK-293T C497(1.11)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C497(1.08)  LDD1600  [1]
 LDCM0399  CL128 HEK-293T C497(1.12)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C497(1.05)  LDD1604  [1]
 LDCM0403  CL16 HEK-293T C497(1.11)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C497(1.19)  LDD1608  [1]
 LDCM0409  CL21 HEK-293T C497(1.24)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C497(1.15)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C497(1.01)  LDD1617  [1]
 LDCM0416  CL28 HEK-293T C497(0.94)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C497(1.05)  LDD1621  [1]
 LDCM0422  CL33 HEK-293T C497(0.94)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C497(0.95)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C497(0.91)  LDD1630  [1]
 LDCM0429  CL4 HEK-293T C497(1.03)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C497(1.09)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C497(1.05)  LDD1635  [1]
 LDCM0435  CL45 HEK-293T C497(1.05)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C497(0.93)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C497(0.95)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C497(1.28)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C497(1.05)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C497(1.02)  LDD1647  [1]
 LDCM0448  CL57 HEK-293T C497(1.07)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C497(1.06)  LDD1652  [1]
 LDCM0453  CL61 HEK-293T C497(1.04)  LDD1656  [1]
 LDCM0456  CL64 HEK-293T C497(0.61)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C497(1.12)  LDD1660  [1]
 LDCM0461  CL69 HEK-293T C497(1.13)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C497(1.08)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C497(1.00)  LDD1669  [1]
 LDCM0469  CL76 HEK-293T C497(1.05)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C497(1.03)  LDD1673  [1]
 LDCM0475  CL81 HEK-293T C497(1.09)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C497(0.92)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C497(0.98)  LDD1682  [1]
 LDCM0482  CL88 HEK-293T C497(1.03)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C497(1.03)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C497(1.11)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C497(0.82)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C497(1.05)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C497(0.98)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402