Details of the Target

General Information of Target

Target ID LDTP09722
Target Name Autism susceptibility gene 2 protein (AUTS2)
Gene Name AUTS2
Gene ID 26053
Synonyms
KIAA0442; Autism susceptibility gene 2 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGPTRGHGLRKKRRSRSQRDRERRSRGGLGAGAAGGGGAGRTRALSLASSSGSDKEDNG
KPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVALKPQERVEKRQTP
LTKKKREALTNGLSFHSKKSRLSHPHHYSSDRENDRNLCQHLGKRKKMPKALRQLKPGQN
SCRDSDSESASGESKGFHRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLF
NTVIVNKDPELGVGTLPEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCP
QVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQR
PPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPP
HISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVA
GHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQ
HTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPF
GSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQI
YHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHP
TGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDG
PSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKD
DKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSES
RKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSR
EAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLA
SMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYR
ELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPR
REHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPT
AGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRERPPSHTLKDIEAR
Target Bioclass
Other
Family
AUTS2 family
Subcellular location
Nucleus
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation. In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1.
Uniprot ID
Q8WXX7
Ensemble ID
ENST00000342771.10
HGNC ID
HGNC:14262

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.F502C .
AN3CA SNV: p.T770I; p.A1242V .
AU565 SNV: p.S1233C .
CAL148 SNV: p.H136N .
CCLP1 SNV: p.A1242T .
CMK SNV: p.W649R .
DU145 SNV: p.G196D; p.G1188Ter .
EFO27 SNV: p.G1051D .
HEC1B SNV: p.R620W .
HT115 SNV: p.R495Q .
HT29 SNV: p.P1033S .
LNCaP clone FGC SNV: p.S856L .
LOXIMVI SNV: p.S82Ter .
LS180 SNV: p.G38D .
MOLT4 SNV: p.S956R .
NALM6 SNV: p.H438P .
NCIH1792 SNV: p.A823D .
NUGC3 SNV: p.A878S .
OCIAML5 SNV: p.S612Y .
PATU8988T SNV: p.P633S .
RH30 SNV: p.L472M .
RKO SNV: p.P361S .
SNU423 SNV: p.P1234S .
SW1573 SNV: p.S272Ter .
SW403 Insertion: p.D989GfsTer4 .
SW480 SNV: p.E931D .
SW620 SNV: p.P1100L .
TOV21G SNV: p.P67Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C299(0.92)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C159(0.98)  LDD1507  [1]
 LDCM0259  AC14 HEK-293T C159(1.02); C299(1.02)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C159(1.04)  LDD1515  [1]
 LDCM0282  AC22 HEK-293T C159(1.12); C299(1.00)  LDD1521  [1]
 LDCM0285  AC25 HEK-293T C159(0.99)  LDD1524  [1]
 LDCM0291  AC30 HEK-293T C159(1.07); C299(1.03)  LDD1530  [1]
 LDCM0294  AC33 HEK-293T C159(1.06)  LDD1533  [1]
 LDCM0299  AC38 HEK-293T C159(1.11); C299(0.99)  LDD1538  [1]
 LDCM0303  AC41 HEK-293T C159(1.04)  LDD1542  [1]
 LDCM0308  AC46 HEK-293T C159(1.19); C299(0.96)  LDD1547  [1]
 LDCM0311  AC49 HEK-293T C159(0.97)  LDD1550  [1]
 LDCM0317  AC54 HEK-293T C159(1.03); C299(1.06)  LDD1556  [1]
 LDCM0320  AC57 HEK-293T C159(0.96)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C159(0.93); C299(1.04)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C159(1.09); C299(0.93)  LDD1565  [1]
 LDCM0356  AKOS034007680 HEK-293T C159(1.08)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C299(1.14)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C159(1.19); C299(1.12)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C159(1.00)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C299(0.98)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C159(1.10)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C159(1.06)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C159(1.02)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C299(1.09)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C159(0.98)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C159(0.98)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C159(1.01)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C299(1.02)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C159(1.03)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C159(1.03)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C159(1.02)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C299(1.12)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C159(0.97)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C159(1.00)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C159(1.03)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C299(1.09)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C159(1.15)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C159(1.10)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C159(1.00)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C299(1.10)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C159(1.02)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C159(0.98)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C159(1.08)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C299(0.96)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C159(1.04)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C159(1.09)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C159(1.00)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C299(1.18)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C159(1.02)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C159(1.17)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C159(0.99)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C159(1.16)  LDD1608  [1]
 LDCM0407  CL2 HEK-293T C159(1.05)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C159(1.23); C299(1.20)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C299(0.97)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C159(1.02)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C159(1.06)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C159(1.02)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C159(1.03)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C159(0.97)  LDD1622  [1]
 LDCM0423  CL34 HEK-293T C159(1.21); C299(1.23)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C299(1.01)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C159(1.06)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C159(0.97)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C159(0.99)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C159(0.97)  LDD1635  [1]
 LDCM0436  CL46 HEK-293T C159(1.08); C299(1.31)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C299(1.00)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C159(1.05)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C159(1.08)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C159(1.00)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C159(1.04)  LDD1647  [1]
 LDCM0449  CL58 HEK-293T C159(1.30); C299(1.26)  LDD1652  [1]
 LDCM0453  CL61 HEK-293T C299(0.96)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C159(1.03)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C159(1.04)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C159(0.94)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C159(1.10)  LDD1660  [1]
 LDCM0463  CL70 HEK-293T C159(1.18); C299(1.19)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C299(1.03)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C159(1.09)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C159(0.99)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C159(1.03)  LDD1673  [1]
 LDCM0476  CL82 HEK-293T C159(1.13); C299(1.29)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C299(1.13)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C159(0.98)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C159(1.08)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C159(0.96)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C159(0.89)  LDD1686  [1]
 LDCM0489  CL94 HEK-293T C159(1.18); C299(1.10)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C299(1.05)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C159(1.13)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C159(1.03)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C159(1.13)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C159(0.94)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C159(0.98)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C299(0.92)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C299(0.77)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C299(0.80)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase p300 (EP300) . Q09472
Polycomb group RING finger protein 5 (PCGF5) . Q86SE9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402