Details of the Target

General Information of Target

Target ID LDTP09596
Target Name Sorting nexin-33 (SNX33)
Gene Name SNX33
Gene ID 257364
Synonyms
SH3PX3; SH3PXD3C; SNX30; Sorting nexin-33; SH3 and PX domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVR
SGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDW
DDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVG
RNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQ
TKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEE
DFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLL
TFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSA
FQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLS
NFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRREL
DFKHMMQNYLRQQILFYQRVGQQLEKTLRMYDNL
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Cytoplasm, cytosol
Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
Uniprot ID
Q8WV41
Ensemble ID
ENST00000308527.6
HGNC ID
HGNC:28468

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C188(2.77)  LDD3310  [2]
BTD
 Probe Info  		C232(0.63)  LDD2138  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		12.70  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0263  AC143 PaTu 8988t C232(0.83)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C232(0.73)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C232(0.78)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C232(0.62)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C232(0.81)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C232(0.67)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C232(0.57)  LDD1148  [7]
 LDCM0271  AC150 PaTu 8988t C232(0.72)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C232(0.75)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C232(0.63)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C232(0.63)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C232(0.62)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C232(0.64)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C232(0.65)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C232(0.62)  LDD2169  [7]
 LDCM0308  AC46 PaTu 8988t C232(0.95)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C232(1.01)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C232(1.00)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C232(0.84)  LDD1190  [7]
 LDCM0313  AC50 PaTu 8988t C232(0.87)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C232(0.94)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C232(0.87)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C232(0.85)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C232(0.94)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C232(0.96)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C232(1.01)  LDD1198  [7]
 LDCM0545  Acetamide MDA-MB-231 C232(0.63)  LDD2138  [3]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0392  CL121 PaTu 8988t C232(1.04)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C232(0.96)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C232(0.86)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C232(0.94)  LDD1274  [7]
 LDCM0403  CL16 PaTu 8988t C232(0.84)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C232(0.75)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C232(0.85)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C232(1.00)  LDD1285  [7]
 LDCM0408  CL20 PaTu 8988t C232(1.01)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C232(0.94)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C232(0.87)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C232(0.80)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C232(0.86)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C232(0.97)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C232(0.82)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C232(0.79)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C232(0.96)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C232(1.03)  LDD1296  [7]
 LDCM0419  CL30 PaTu 8988t C232(0.79)  LDD1298  [7]
 LDCM0420  CL31 PaTu 8988t C232(0.66)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C232(0.59)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C232(0.54)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C232(0.57)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C232(0.55)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C232(0.61)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C232(0.49)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C232(0.65)  LDD1307  [7]
 LDCM0430  CL40 PaTu 8988t C232(0.73)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C232(0.43)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C232(0.58)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C232(0.66)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C232(0.53)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C232(0.65)  LDD1314  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C188(2.23)  LDD1702  [3]
 LDCM0427  Fragment51 PaTu 8988t C232(0.72)  LDD1306  [7]
 LDCM0022  KB02 769-P C188(2.20)  LDD2246  [2]
 LDCM0023  KB03 769-P C188(2.54)  LDD2663  [2]
 LDCM0024  KB05 COLO792 C188(2.77)  LDD3310  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C232(0.49)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Dynamin-1 (DNM1) Dynamin/Fzo/YdjA family Q05193
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) . Q13444
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Sorting nexin-33 (SNX33) Sorting nexin family Q8WV41
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 575 (ZNF575) Krueppel C2H2-type zinc-finger protein family Q86XF7
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Sorting nexin-9 (SNX9) Sorting nexin family Q9Y5X1
Actin nucleation-promoting factor WAS (WAS) . P42768
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.