Details of the Target

General Information of Target

Target ID LDTP09559
Target Name Protein FAM222B (FAM222B)
Gene Name FAM222B
Gene ID 55731
Synonyms
C17orf63; Protein FAM222B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIK
IFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTR
ARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPP
PQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALAHQGLQHPHNPLLHGGRKMPDSDAPP
NVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISR
SLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRVPTGYPSDL
KPVTWNQHQLAHLQQMCSEASGTPAPGLTGKHAAGRELAGPGFVGKAPAYPQELCLAQSF
HLKPPLEKPTPSPPVNGMAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAMPFHGGQP
TGAPLDCAAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRA
PGNRAPDPTESRSLHIQHPGYR
Target Bioclass
Other
Family
FAM222 family
Uniprot ID
Q8WU58
Ensemble ID
ENST00000452648.8
HGNC ID
HGNC:25563

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.25  LDD0066  [1]
AHL-Pu-1
 Probe Info  		C288(3.11)  LDD0170  [2]
IPM
 Probe Info  		C288(0.00); C377(0.00); C525(0.00)  LDD2156  [3]
AOyne
 Probe Info  		13.70  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C288(3.11)  LDD0170  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Tubulin--tyrosine ligase-like protein 12 (TTLL12) Tubulin--tyrosine ligase family Q14166
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FosB (FOSB) BZIP family P53539
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cornifelin (CNFN) Cornifelin family Q9BYD5
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Protein Mis18-beta (OIP5) Mis18 family O43482
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Cell division cycle-associated protein 4 (CDCA4) . Q9BXL8
Four and a half LIM domains protein 3 (FHL3) . Q13643
Leucine-rich repeat-containing protein 61 (LRRC61) . Q9BV99
PDZ and LIM domain protein 4 (PDLIM4) . P50479
Ubiquilin-2 (UBQLN2) . Q9UHD9
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.