Details of the Target

General Information of Target

Target ID LDTP09526
Target Name Zinc finger protein 90 homolog (ZFP90)
Gene Name ZFP90
Gene ID 146198
Synonyms
KIAA1954; ZNF756; Zinc finger protein 90 homolog; Zfp-90; Zinc finger protein 756
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRPPTAAPQESVTFKDVSVDFTQEEWYHVDPAQRSLYRDVMLENYSHLVSLGYQVSKP
EVIFKLEQGEEPWISEGEIQRPFYPDWKTRPEVKSSHLQQDVSEVSHCTHDLLHATLEDS
WDVSSQLDRQQENWKRHLGSEASTQKKIITPQENFEQNKFGENSRLNTNLVTQLNIPARI
RPSECETLGSNLGHNADLLNENNILAKKKPYKCDKCRKAFIHRSSLTKHEKTHKGEGAFP
NGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQH
ENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTH
SGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGK
PYQSSNYSIDFKHSTSLTQDESTLTEVKSYHCNDCGEDFSHITDFTDHQRIHTAENPYDC
EQAFSQQAISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSL
TQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECNECGRAFRKKTNLHDHQ
RIHTGEKPYSCKECGKNFSRSSALTKHQRIHTRNKL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.; [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).
Uniprot ID
Q8TF47
Ensemble ID
ENST00000398253.6
HGNC ID
HGNC:23329

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.A488V .
EFO27 Deletion: p.H233QfsTer8 .
HCT15 SNV: p.K504R .
MCC26 SNV: p.E153K .
MELHO SNV: p.M1? .
MEWO SNV: p.Q320Ter .
RD SNV: p.F291V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C378(1.62)  LDD3407  [1]
Acrolein
 Probe Info  		H137(0.00); K146(0.00)  LDD0222  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C378(1.08)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C378(0.91)  LDD1512  [4]
 LDCM0280  AC20 HEK-293T C378(1.09)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C378(1.07)  LDD1521  [4]
 LDCM0288  AC28 HEK-293T C378(0.95)  LDD1527  [4]
 LDCM0291  AC30 HEK-293T C378(0.98)  LDD1530  [4]
 LDCM0297  AC36 HEK-293T C378(1.00)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C378(0.95)  LDD1538  [4]
 LDCM0301  AC4 HEK-293T C378(1.02)  LDD1540  [4]
 LDCM0306  AC44 HEK-293T C378(1.15)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C378(1.00)  LDD1547  [4]
 LDCM0315  AC52 HEK-293T C378(1.04)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C378(1.09)  LDD1556  [4]
 LDCM0323  AC6 HEK-293T C378(1.03)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C378(1.10)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C378(0.98)  LDD1565  [4]
 LDCM0108  Chloroacetamide HeLa H137(0.00); K146(0.00)  LDD0222  [2]
 LDCM0368  CL10 HEK-293T C378(0.96)  LDD1572  [4]
 LDCM0372  CL103 HEK-293T C378(1.06)  LDD1576  [4]
 LDCM0376  CL107 HEK-293T C378(1.05)  LDD1580  [4]
 LDCM0381  CL111 HEK-293T C378(1.23)  LDD1585  [4]
 LDCM0385  CL115 HEK-293T C378(1.36)  LDD1589  [4]
 LDCM0389  CL119 HEK-293T C378(0.92)  LDD1593  [4]
 LDCM0394  CL123 HEK-293T C378(1.17)  LDD1598  [4]
 LDCM0398  CL127 HEK-293T C378(1.00)  LDD1602  [4]
 LDCM0402  CL15 HEK-293T C378(1.60)  LDD1606  [4]
 LDCM0408  CL20 HEK-293T C378(1.17)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C378(0.99)  LDD1614  [4]
 LDCM0415  CL27 HEK-293T C378(1.13)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C378(1.10)  LDD1622  [4]
 LDCM0421  CL32 HEK-293T C378(1.18)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C378(0.98)  LDD1627  [4]
 LDCM0428  CL39 HEK-293T C378(1.08)  LDD1632  [4]
 LDCM0434  CL44 HEK-293T C378(1.04)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C378(0.98)  LDD1640  [4]
 LDCM0447  CL56 HEK-293T C378(1.16)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C378(1.00)  LDD1652  [4]
 LDCM0455  CL63 HEK-293T C378(1.19)  LDD1658  [4]
 LDCM0460  CL68 HEK-293T C378(1.05)  LDD1663  [4]
 LDCM0463  CL70 HEK-293T C378(0.93)  LDD1666  [4]
 LDCM0473  CL8 HEK-293T C378(1.02)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C378(1.10)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C378(1.00)  LDD1679  [4]
 LDCM0481  CL87 HEK-293T C378(1.34)  LDD1684  [4]
 LDCM0487  CL92 HEK-293T C378(0.98)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C378(0.96)  LDD1692  [4]
 LDCM0494  CL99 HEK-293T C378(1.19)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C378(1.32)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C378(1.37)  LDD1671  [4]
 LDCM0022  KB02 HEK-293T C480(1.10)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C480(1.00)  LDD1497  [4]
 LDCM0024  KB05 RKO C378(1.62)  LDD3407  [1]
 LDCM0109  NEM HeLa H137(0.00); K146(0.00)  LDD0225  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3) TrmE GTPase family Q969Y2
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Forkhead box protein P3 (FOXP3) . Q9BZS1
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Cyclin-C (CCNC) Cyclin family P24863
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Mitochondrial assembly of ribosomal large subunit protein 1 (MALSU1) Iojap/RsfS family Q96EH3
Tudor and KH domain-containing protein (TDRKH) Tdrkh family Q9Y2W6
Tektin-4 (TEKT4) Tektin family Q8WW24
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Rhombotin-1 (LMO1) . P25800
TBC1 domain family member 22B (TBC1D22B) . Q9NU19

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402