Details of the Target

General Information of Target

Target ID LDTP09476
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAMTS16)
Gene Name ADAMTS16
Gene ID 170690
Synonyms
KIAA2029; A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM-TS 16; ADAM-TS16; ADAMTS-16; EC 3.4.24.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEY
DLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVA
PGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL
RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRL
GLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDK
KMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH
TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTIN
EDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLH
KFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKA
LWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSR
TCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRF
RGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERV
GCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMN
VSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIV
ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL
KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY
DSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSA
RAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAE
KYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTA
SCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLV
PQHGMCSHKFYGKQCCKTCSKSNL
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Uniprot ID
Q8TE57
Ensemble ID
ENST00000274181.7
HGNC ID
HGNC:17108

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.R1046P .
CHL1 SNV: p.W995Ter .
DANG SNV: p.V851A .
DU145 SNV: p.L531M .
EFO27 SNV: p.Y66F .
HCC1143 SNV: p.P495T .
HCC15 SNV: p.D700H .
HCT15 SNV: p.P26H; p.Q126H; p.L267S .
HT SNV: p.S1150P .
IGR1 SNV: p.S157F .
Ishikawa (Heraklio) 02 ER Deletion: p.G750VfsTer30 .
K562 Insertion: p.L507YfsTer7 .
KPL1 SNV: p.R1158Q .
LS123 SNV: p.P928T .
LS180 SNV: p.M779T .
LS513 SNV: p.K901R .
MCF7 SNV: p.R1158Q .
MEWO SNV: p.R545C; p.G603E .
MFE319 SNV: p.R44C; p.Q1152Ter .
NCIH1155 Substitution: p.S1058G .
NCIH2172 SNV: p.G424C; p.G1162C .
NCIH2286 Deletion: p.G10AfsTer92 .
NCIH358 SNV: p.Q869K .
NCIH446 SNV: p.S150F .
NUGC3 SNV: p.K1014R .
RH30 SNV: p.L483I; p.A1108S .
RPMI8226 SNV: p.M1? .
SUPT1 SNV: p.T317M .
SW620 SNV: p.A19E .
TE11 SNV: p.A36G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1138(1.42); C1142(1.42); C927(1.30); C939(1.30)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0276  AC17 PaTu 8988t C399(1.17); C411(1.17)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C399(1.23); C411(1.23)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C399(1.16); C411(1.16)  LDD1157  [1]
 LDCM0280  AC20 PaTu 8988t C399(1.20); C411(1.20)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C399(1.15); C411(1.15)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C399(1.21); C411(1.21)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C399(1.03); C411(1.03)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C399(1.08); C411(1.08)  LDD1163  [1]
 LDCM0296  AC35 PaTu 8988t C399(1.20); C411(1.20)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C399(1.47); C411(1.47)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C399(1.23); C411(1.23)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C399(1.64); C411(1.64)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C399(1.42); C411(1.42)  LDD1179  [1]
 LDCM0302  AC40 PaTu 8988t C399(2.46); C411(2.46)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C399(1.57); C411(1.57)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C399(2.95); C411(2.95)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C399(1.38); C411(1.38)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C399(2.28); C411(2.28)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C399(2.95); C411(2.95)  LDD1186  [1]
 LDCM0320  AC57 PaTu 8988t C399(1.69); C411(1.69)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C399(2.35); C411(2.35)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C399(1.59); C411(1.59)  LDD1201  [1]
 LDCM0324  AC60 PaTu 8988t C399(1.86); C411(1.86)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C399(2.11); C411(2.11)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C399(1.64); C411(1.64)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C399(1.42); C411(1.42)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C399(1.38); C411(1.38)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C399(1.63); C411(1.63)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C399(1.49); C411(1.49)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C399(1.51); C411(1.51)  LDD1210  [1]
 LDCM0349  AC83 PaTu 8988t C399(0.85); C411(0.85)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C399(0.79); C411(0.79)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C399(0.93); C411(0.93)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C399(0.86); C411(0.86)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C399(0.97); C411(0.97)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C399(1.06); C411(1.06)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C399(0.68); C411(0.68)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C399(1.04); C411(1.04)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C399(1.10); C411(1.10)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C399(0.85); C411(0.85)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C399(0.84); C411(0.84)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C399(1.00); C411(1.00)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C399(1.05); C411(1.05)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C399(0.81); C411(0.81)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C399(0.83); C411(0.83)  LDD1243  [1]
 LDCM0020  ARS-1620 HCC44 C1138(1.42); C1142(1.42); C927(1.30); C939(1.30)  LDD0078  [1]
 LDCM0374  CL105 PaTu 8988t C399(1.12); C411(1.12)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C399(0.97); C411(0.97)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C399(0.98); C411(0.98)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C399(1.13); C411(1.13)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C399(1.09); C411(1.09)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C399(1.26); C411(1.26)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C399(1.31); C411(1.31)  LDD1260  [1]
 LDCM0387  CL117 PaTu 8988t C399(1.60); C411(1.60)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C399(2.01); C411(2.01)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C399(2.28); C411(2.28)  LDD1268  [1]
 LDCM0391  CL120 PaTu 8988t C399(1.51); C411(1.51)  LDD1270  [1]
 LDCM0396  CL125 PaTu 8988t C399(1.89); C411(1.89)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C399(1.74); C411(1.74)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C399(1.65); C411(1.65)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C399(1.52); C411(1.52)  LDD1278  [1]
 LDCM0022  KB02 ICC3 C652(2.08)  LDD2391  [2]
 LDCM0023  KB03 ICC3 C652(2.15)  LDD2808  [2]
 LDCM0024  KB05 OAW-42 C652(2.23)  LDD3369  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840