Details of the Target

General Information of Target

Target ID LDTP09370
Target Name POC1 centriolar protein homolog B (POC1B)
Gene Name POC1B
Gene ID 282809
Synonyms
WDR51B; POC1 centriolar protein homolog B; Pix1; Proteome of centriole protein 1B; WD repeat-containing protein 51B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK
DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA
SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN
NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG
NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN
FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP
VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES
QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS
Target Bioclass
Other
Family
WD repeat POC1 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity.
Uniprot ID
Q8TC44
Ensemble ID
ENST00000313546.8
HGNC ID
HGNC:30836

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.Q468R .
HT SNV: p.V108A .
NALM6 SNV: p.I328F DBIA    Probe Info 
NCIH1155 SNV: p.D382E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C306(0.84)  LDD2228  [1]
IA-alkyne
 Probe Info  		C306(5.07)  LDD1706  [2]
DBIA
 Probe Info  		C388(5.37); C401(5.37)  LDD0080  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0263  AC143 PaTu 8988t C178(1.10); C200(1.10)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C178(1.35); C200(1.35)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C178(1.00); C200(1.00)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C178(1.31); C200(1.31)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C178(1.29); C200(1.29)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C178(1.15); C200(1.15)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C178(1.16); C200(1.16)  LDD1148  [3]
 LDCM0271  AC150 PaTu 8988t C178(1.65); C200(1.65)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C178(1.60); C200(1.60)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C178(1.60); C200(1.60)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C178(1.61); C200(1.61)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C178(1.50); C200(1.50)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C178(1.44); C200(1.44)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C178(1.42); C200(1.42)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C178(1.45); C200(1.45)  LDD2169  [3]
 LDCM0276  AC17 PaTu 8988t C178(1.23); C200(1.23)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C178(1.64); C200(1.64)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C178(0.97); C200(0.97)  LDD1157  [3]
 LDCM0280  AC20 PaTu 8988t C178(0.92); C200(0.92)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C178(1.15); C200(1.15)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C178(1.02); C200(1.02)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C178(1.33); C200(1.33)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C178(1.00); C200(1.00)  LDD1163  [3]
 LDCM0308  AC46 PaTu 8988t C178(1.21); C200(1.21)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C178(1.64); C200(1.64)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C178(1.23); C200(1.23)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C178(2.36); C200(2.36)  LDD1190  [3]
 LDCM0313  AC50 PaTu 8988t C178(2.05); C200(2.05)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C178(1.90); C200(1.90)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C178(2.05); C200(2.05)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C178(2.75); C200(2.75)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C178(2.06); C200(2.06)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C178(1.62); C200(1.62)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C178(1.98); C200(1.98)  LDD1198  [3]
 LDCM0349  AC83 PaTu 8988t C178(0.96); C200(0.96)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C178(0.58); C200(0.58)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C178(0.86); C200(0.86)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C178(0.66); C200(0.66)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C178(0.78); C200(0.78)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C178(0.82); C200(0.82)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C178(0.71); C200(0.71)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C178(1.05); C200(1.05)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C178(1.02); C200(1.02)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C178(1.01); C200(1.01)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C178(0.68); C200(0.68)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C178(0.73); C200(0.73)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C178(0.83); C200(0.83)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C178(0.90); C200(0.90)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C178(0.77); C200(0.77)  LDD1243  [3]
 LDCM0020  ARS-1620 HCC44 C388(1.25); C401(1.25)  LDD2171  [3]
 LDCM0367  CL1 PaTu 8988t C178(1.06); C200(1.06)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C178(1.47); C200(1.47)  LDD1247  [3]
 LDCM0374  CL105 PaTu 8988t C178(0.99); C200(0.99)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C178(1.08); C200(1.08)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C178(1.06); C200(1.06)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C178(1.34); C200(1.34)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C178(1.24); C200(1.24)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C178(0.91); C200(0.91)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C178(1.05); C200(1.05)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C178(1.39); C200(1.39)  LDD1260  [3]
 LDCM0390  CL12 PaTu 8988t C178(0.91); C200(0.91)  LDD1269  [3]
 LDCM0392  CL121 PaTu 8988t C178(1.62); C200(1.62)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C178(1.61); C200(1.61)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C178(2.81); C200(2.81)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C178(1.95); C200(1.95)  LDD1274  [3]
 LDCM0400  CL13 PaTu 8988t C178(1.24); C200(1.24)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C178(1.38); C200(1.38)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C178(1.68); C200(1.68)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C178(0.96); C200(0.96)  LDD1286  [3]
 LDCM0418  CL3 PaTu 8988t C178(1.15); C200(1.15)  LDD1297  [3]
 LDCM0420  CL31 PaTu 8988t C178(1.06); C200(1.06)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C178(1.18); C200(1.18)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C178(2.75); C200(2.75)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C178(1.45); C200(1.45)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C178(1.33); C200(1.33)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C178(1.64); C200(1.64)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C178(1.36); C200(1.36)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C178(1.26); C200(1.26)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C178(1.04); C200(1.04)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C178(0.79); C200(0.79)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C178(1.39); C200(1.39)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C178(1.62); C200(1.62)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C178(1.30); C200(1.30)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C178(1.07); C200(1.07)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C178(1.26); C200(1.26)  LDD1314  [3]
 LDCM0440  CL5 PaTu 8988t C178(1.11); C200(1.11)  LDD1319  [3]
 LDCM0451  CL6 PaTu 8988t C178(1.16); C200(1.16)  LDD1330  [3]
 LDCM0453  CL61 PaTu 8988t C178(0.97); C200(0.97)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C178(1.26); C200(1.26)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C178(1.11); C200(1.11)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C178(1.29); C200(1.29)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C178(1.11); C200(1.11)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C178(1.02); C200(1.02)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C178(1.35); C200(1.35)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C178(1.67); C200(1.67)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C178(1.12); C200(1.12)  LDD1340  [3]
 LDCM0462  CL7 PaTu 8988t C178(1.16); C200(1.16)  LDD1341  [3]
 LDCM0463  CL70 PaTu 8988t C178(1.54); C200(1.54)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C178(1.13); C200(1.13)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C178(0.96); C200(0.96)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C178(1.31); C200(1.31)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C178(1.39); C200(1.39)  LDD1346  [3]
 LDCM0473  CL8 PaTu 8988t C178(1.30); C200(1.30)  LDD1352  [3]
 LDCM0484  CL9 PaTu 8988t C178(1.27); C200(1.27)  LDD1363  [3]
 LDCM0634  CY-0357 Hep-G2 C306(0.84)  LDD2228  [1]
 LDCM0468  Fragment33 PaTu 8988t C178(1.32); C200(1.32)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C178(1.33); C200(1.33)  LDD1306  [3]
 LDCM0022  KB02 HCT 116 C388(5.37); C401(5.37)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C388(2.38); C401(2.38)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C388(4.04); C401(4.04)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C388(1.25); C401(1.25)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear migration protein nudC (NUDC) NudC family Q9Y266

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019