Details of the Target

General Information of Target

Target ID LDTP09341
Target Name Protein cornichon homolog 3 (CNIH3)
Gene Name CNIH3
Gene ID 149111
Synonyms
Protein cornichon homolog 3; CNIH-3; Cornichon family AMPA receptor auxiliary protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQCNPVHARERLRNIERI
CFLLRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHFWRYFHCPADSSELAYDPP
VVMNADTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS
Target Bioclass
Transporter and channel
Family
Cornichon family
Subcellular location
Postsynaptic cell membrane
Function
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.
Uniprot ID
Q8TBE1
Ensemble ID
ENST00000272133.4
HGNC ID
HGNC:26802

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C45(2.31)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C45(1.21)  LDD1507  [2]
 LDCM0270  AC15 HEK-293T C45(0.93)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C45(0.84)  LDD1515  [2]
 LDCM0283  AC23 HEK-293T C45(0.80)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C45(1.04)  LDD1524  [2]
 LDCM0292  AC31 HEK-293T C45(1.21)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C45(0.89)  LDD1533  [2]
 LDCM0300  AC39 HEK-293T C45(0.74)  LDD1539  [2]
 LDCM0303  AC41 HEK-293T C45(0.78)  LDD1542  [2]
 LDCM0309  AC47 HEK-293T C45(0.96)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C45(0.79)  LDD1550  [2]
 LDCM0318  AC55 HEK-293T C45(0.83)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C45(1.01)  LDD1559  [2]
 LDCM0327  AC63 HEK-293T C45(0.90)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C45(1.36)  LDD1568  [2]
 LDCM0356  AKOS034007680 HEK-293T C45(0.91)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C45(0.77)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C45(1.16)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C45(0.98)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C45(0.89)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C45(1.05)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C45(0.96)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C45(0.84)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C45(1.00)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C45(1.01)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C45(1.13)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C45(1.01)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C45(1.13)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C45(1.08)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C45(1.01)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C45(1.00)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C45(0.83)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C45(0.94)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C45(1.18)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C45(0.86)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C45(0.80)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C45(0.99)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C45(0.90)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C45(0.89)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C45(0.96)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C45(0.91)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C45(0.79)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C45(1.26)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C45(0.83)  LDD1608  [2]
 LDCM0411  CL23 HEK-293T C45(1.19)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C45(0.85)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C45(0.95)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C45(0.94)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C45(1.01)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C45(1.11)  LDD1622  [2]
 LDCM0424  CL35 HEK-293T C45(0.97)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C45(0.73)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C45(0.88)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C45(1.05)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C45(0.89)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C45(0.95)  LDD1635  [2]
 LDCM0437  CL47 HEK-293T C45(1.05)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C45(0.69)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C45(0.96)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C45(1.13)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C45(0.95)  LDD1647  [2]
 LDCM0450  CL59 HEK-293T C45(0.85)  LDD1653  [2]
 LDCM0453  CL61 HEK-293T C45(0.80)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C45(0.81)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C45(1.02)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C45(0.82)  LDD1660  [2]
 LDCM0464  CL71 HEK-293T C45(1.07)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C45(0.94)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C45(1.00)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C45(0.85)  LDD1673  [2]
 LDCM0477  CL83 HEK-293T C45(1.04)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C45(0.92)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C45(0.89)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C45(1.12)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C45(0.87)  LDD1686  [2]
 LDCM0490  CL95 HEK-293T C45(1.10)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C45(0.99)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C45(0.91)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C45(0.72)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C45(1.00)  LDD1671  [2]
 LDCM0022  KB02 8305C C45(1.87)  LDD2248  [1]
 LDCM0023  KB03 8305C C45(5.15)  LDD2665  [1]
 LDCM0024  KB05 IGR37 C45(2.31)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402