Details of the Target

General Information of Target

Target ID LDTP09331
Target Name Protein NDNF (NDNF)
Gene Name NDNF
Gene ID 79625
Synonyms
C4orf31; Protein NDNF; Neuron-derived neurotrophic factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDT
PKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINE
EGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFKVYATTTPESDQPYPELPYDP
RVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDAFMMA
PKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFT
VSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGA
KFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVR
LKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCI
YKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKS
YLLDVYVIGHGGHSVKYQSKVVKTRKFC
Target Bioclass
Other
Subcellular location
Secreted
Function
Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.
Uniprot ID
Q8TB73
Ensemble ID
ENST00000379692.9
HGNC ID
HGNC:26256

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K358(6.25); K361(7.09)  LDD0277  [1]
DBIA
 Probe Info  		C462(1.09)  LDD1511  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C462(0.89)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C462(0.97)  LDD1523  [2]
 LDCM0289  AC29 HEK-293T C462(1.05)  LDD1528  [2]
 LDCM0293  AC32 HEK-293T C462(1.16)  LDD1532  [2]
 LDCM0298  AC37 HEK-293T C462(1.09)  LDD1537  [2]
 LDCM0302  AC40 HEK-293T C462(1.04)  LDD1541  [2]
 LDCM0307  AC45 HEK-293T C462(1.05)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C462(1.28)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C462(1.25)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C462(0.92)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C462(1.12)  LDD1558  [2]
 LDCM0325  AC61 HEK-293T C462(1.14)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C462(1.47)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C462(1.23)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C462(1.09)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C462(1.17)  LDD1514  [2]
 LDCM0372  CL103 HEK-293T C462(0.86)  LDD1576  [2]
 LDCM0376  CL107 HEK-293T C462(0.85)  LDD1580  [2]
 LDCM0381  CL111 HEK-293T C462(0.94)  LDD1585  [2]
 LDCM0385  CL115 HEK-293T C462(1.26)  LDD1589  [2]
 LDCM0389  CL119 HEK-293T C462(1.14)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C462(1.10)  LDD1594  [2]
 LDCM0394  CL123 HEK-293T C462(0.84)  LDD1598  [2]
 LDCM0398  CL127 HEK-293T C462(0.93)  LDD1602  [2]
 LDCM0402  CL15 HEK-293T C462(1.29)  LDD1606  [2]
 LDCM0409  CL21 HEK-293T C462(1.07)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C462(1.03)  LDD1616  [2]
 LDCM0415  CL27 HEK-293T C462(1.04)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C462(0.89)  LDD1622  [2]
 LDCM0422  CL33 HEK-293T C462(1.18)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C462(1.14)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C462(0.92)  LDD1632  [2]
 LDCM0435  CL45 HEK-293T C462(1.39)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C462(1.07)  LDD1642  [2]
 LDCM0448  CL57 HEK-293T C462(1.14)  LDD1651  [2]
 LDCM0452  CL60 HEK-293T C462(1.21)  LDD1655  [2]
 LDCM0455  CL63 HEK-293T C462(0.96)  LDD1658  [2]
 LDCM0461  CL69 HEK-293T C462(1.19)  LDD1664  [2]
 LDCM0465  CL72 HEK-293T C462(1.23)  LDD1668  [2]
 LDCM0475  CL81 HEK-293T C462(1.26)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C462(0.99)  LDD1681  [2]
 LDCM0481  CL87 HEK-293T C462(1.00)  LDD1684  [2]
 LDCM0484  CL9 HEK-293T C462(1.07)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C462(1.19)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C462(1.60)  LDD1694  [2]
 LDCM0494  CL99 HEK-293T C462(1.00)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C462(0.85)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C462(1.07)  LDD1671  [2]
 LDCM0022  KB02 BRX211 C225(1.72)  LDD2268  [3]
 LDCM0023  KB03 BRX211 C225(2.03)  LDD2685  [3]
 LDCM0024  KB05 BRX211 C225(1.98)  LDD3102  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840