Details of the Target

General Information of Target

Target ID LDTP09037
Target Name Zinc finger protein 511 (ZNF511)
Gene Name ZNF511
Gene ID 118472
Synonyms
Zinc finger protein 511
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLPPALCARLAAGPGAAEPLPVERDPAAGAAPFRFVARPVRFPREHQFFEDGDVQRHLY
LQDVIMQVADVPEKPRVPAFACQVAGCCQVFDALDDYEHHYHTLHGNVCSFCKRAFPSGH
LLDAHILEWHDSLFQILSERQDMYQCLVEGCTEKFKTSRDRKDHMVRMHLYPADFRFDKP
KKSRSPASAEAPGDSGERSEGEAMEICSEPVAASPAPAGERRIYRHRIPSTICFGQGAAR
GFKSNKKKTKQC
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8NB15
Ensemble ID
ENST00000359035.4
HGNC ID
HGNC:28445

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C233(1.93)  LDD3325  [1]
NAIA_5
 Probe Info  		C8(0.00); C207(0.00)  LDD2224  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
HHS-465
 Probe Info  		N.A.  LDD2240  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C233(1.02)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C207(0.64); C233(1.16)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C207(1.07)  LDD1510  [6]
 LDCM0277  AC18 HEK-293T C233(1.11)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C207(0.82); C233(1.32)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C233(1.01)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C207(1.01)  LDD1519  [6]
 LDCM0286  AC26 HEK-293T C233(0.99)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C207(0.84); C233(1.14)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C207(0.93)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C207(0.70); C233(1.35)  LDD1529  [6]
 LDCM0295  AC34 HEK-293T C233(1.02)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C207(0.80); C233(1.05)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C207(1.42)  LDD1536  [6]
 LDCM0301  AC4 HEK-293T C207(1.53)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C233(1.24)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C207(0.63); C233(1.14)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C207(1.07)  LDD1545  [6]
 LDCM0313  AC50 HEK-293T C233(1.13)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C207(0.90); C233(1.10)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C207(1.78)  LDD1554  [6]
 LDCM0321  AC58 HEK-293T C233(1.03)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C207(0.79); C233(1.16)  LDD1561  [6]
 LDCM0324  AC60 HEK-293T C207(1.20)  LDD1563  [6]
 LDCM0632  CL-Sc Hep-G2 C8(0.73)  LDD2227  [2]
 LDCM0369  CL100 HEK-293T C207(1.21)  LDD1573  [6]
 LDCM0371  CL102 HEK-293T C207(0.68)  LDD1575  [6]
 LDCM0373  CL104 HEK-293T C207(1.11)  LDD1577  [6]
 LDCM0375  CL106 HEK-293T C207(0.87)  LDD1579  [6]
 LDCM0377  CL108 HEK-293T C207(1.25)  LDD1581  [6]
 LDCM0380  CL110 HEK-293T C207(0.94)  LDD1584  [6]
 LDCM0382  CL112 HEK-293T C207(1.20)  LDD1586  [6]
 LDCM0384  CL114 HEK-293T C207(0.75)  LDD1588  [6]
 LDCM0386  CL116 HEK-293T C207(0.88)  LDD1590  [6]
 LDCM0388  CL118 HEK-293T C207(0.88)  LDD1592  [6]
 LDCM0391  CL120 HEK-293T C207(1.02)  LDD1595  [6]
 LDCM0393  CL122 HEK-293T C207(0.90)  LDD1597  [6]
 LDCM0395  CL124 HEK-293T C207(1.22)  LDD1599  [6]
 LDCM0397  CL126 HEK-293T C207(1.08)  LDD1601  [6]
 LDCM0399  CL128 HEK-293T C207(1.05)  LDD1603  [6]
 LDCM0401  CL14 HEK-293T C207(0.80)  LDD1605  [6]
 LDCM0403  CL16 HEK-293T C207(1.27)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C233(1.14)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C207(0.68); C233(1.09)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C207(0.80)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C207(1.34)  LDD1612  [6]
 LDCM0414  CL26 HEK-293T C207(0.85)  LDD1618  [6]
 LDCM0416  CL28 HEK-293T C207(1.15)  LDD1620  [6]
 LDCM0419  CL30 HEK-293T C233(1.02)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C207(0.76); C233(1.09)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C207(0.86)  LDD1625  [6]
 LDCM0429  CL4 HEK-293T C207(1.14)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C207(1.24)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C233(1.01)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C207(0.60); C233(1.06)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C207(0.89)  LDD1638  [6]
 LDCM0441  CL50 HEK-293T C207(1.38)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C207(1.02)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C233(0.91)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C207(1.08); C233(1.24)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C207(1.35)  LDD1650  [6]
 LDCM0451  CL6 HEK-293T C233(0.98)  LDD1654  [6]
 LDCM0454  CL62 HEK-293T C207(1.04)  LDD1657  [6]
 LDCM0456  CL64 HEK-293T C207(0.97)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C233(1.02)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C207(0.83); C233(1.18)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C207(0.98)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C207(0.79); C233(1.20)  LDD1665  [6]
 LDCM0467  CL74 HEK-293T C207(0.69)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C207(0.91)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C233(0.98)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C207(0.68); C233(1.29)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C207(0.89)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C207(0.92)  LDD1677  [6]
 LDCM0480  CL86 HEK-293T C207(0.86)  LDD1683  [6]
 LDCM0482  CL88 HEK-293T C207(1.40)  LDD1685  [6]
 LDCM0485  CL90 HEK-293T C233(1.11)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C207(0.67); C233(1.18)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C207(0.89)  LDD1690  [6]
 LDCM0493  CL98 HEK-293T C207(0.84)  LDD1696  [6]
 LDCM0634  CY-0357 Hep-G2 C207(0.69)  LDD2228  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C233(1.62)  LDD1702  [7]
 LDCM0427  Fragment51 HEK-293T C207(1.13)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C233(1.01)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C233(1.06)  LDD1497  [6]
 LDCM0024  KB05 UACC257 C233(1.93)  LDD3325  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Insulin gene enhancer protein ISL-1 (ISL1) . P61371
LIM/homeobox protein Lhx2 (LHX2) . P50458
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Heat shock factor 2-binding protein (HSF2BP) . O75031
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
Rhombotin-1 (LMO1) . P25800
Transmembrane and coiled-coil domain-containing protein 6 (TMCO6) . Q96DC7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761