Details of the Target

General Information of Target

Target ID LDTP08985
Target Name BMP-binding endothelial regulator protein (BMPER)
Gene Name BMPER
Gene ID 168667
Synonyms
KIAA1965; BMP-binding endothelial regulator protein; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2; hCV2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLWFSGVGALAERYCRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQIP
FITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFK
WQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCVFEGVQYQEGEEFQ
PEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPFGSCLF
RSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPEDIKV
CKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCCPICTEK
PGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKS
VELVLGESRVSLQQHLTVRWNGSRIALPCRAPHFHIDLDGYLLKVTTKAGLEISWDGDSF
VEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQRK
PVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCE
SFLAYTRACQREGIKVHWEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEIGPCNKPCV
AGCHCPANLVLHKGRCIKPVLCPQR
Target Bioclass
Other
Subcellular location
Secreted
Function Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
Uniprot ID
Q8N8U9
Ensemble ID
ENST00000297161.6
HGNC ID
HGNC:24154

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C560(0.95)  LDD1509  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C560(0.95)  LDD1509  [1]
 LDCM0278  AC19 HEK-293T C560(0.67)  LDD1517  [1]
 LDCM0281  AC21 HEK-293T C105(0.92)  LDD1520  [1]
 LDCM0284  AC24 HEK-293T C584(1.03); C589(1.03); C591(1.03)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C560(0.87)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C105(0.93)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C560(0.76)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C584(1.02); C589(1.02); C591(1.02)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C560(0.97)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C105(1.22)  LDD1537  [1]
 LDCM0302  AC40 HEK-293T C584(0.98); C589(0.98); C591(0.98)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C560(1.08)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C105(1.04)  LDD1546  [1]
 LDCM0310  AC48 HEK-293T C584(0.98); C589(0.98); C591(0.98)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C105(0.00)  LDD1551  [1]
 LDCM0314  AC51 HEK-293T C560(0.91)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C105(1.12)  LDD1555  [1]
 LDCM0319  AC56 HEK-293T C584(1.07); C589(1.07); C591(1.07)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C560(0.98)  LDD1561  [1]
 LDCM0325  AC61 HEK-293T C105(0.93)  LDD1564  [1]
 LDCM0328  AC64 HEK-293T C584(0.94); C589(0.94); C591(0.94)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C584(0.94); C589(0.94); C591(0.94)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C105(1.06)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C584(1.01); C589(1.01); C591(1.01)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C584(1.21); C589(1.21); C591(1.21)  LDD1594  [1]
 LDCM0406  CL19 HEK-293T C560(1.12)  LDD1610  [1]
 LDCM0409  CL21 HEK-293T C105(0.89)  LDD1613  [1]
 LDCM0412  CL24 HEK-293T C584(1.21); C589(1.21); C591(1.21)  LDD1616  [1]
 LDCM0420  CL31 HEK-293T C560(1.13)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C105(1.77)  LDD1626  [1]
 LDCM0425  CL36 HEK-293T C584(1.36); C589(1.36); C591(1.36)  LDD1629  [1]
 LDCM0433  CL43 HEK-293T C560(0.82)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C105(1.00)  LDD1639  [1]
 LDCM0438  CL48 HEK-293T C584(1.18); C589(1.18); C591(1.18)  LDD1642  [1]
 LDCM0446  CL55 HEK-293T C560(1.01)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C105(3.77)  LDD1651  [1]
 LDCM0452  CL60 HEK-293T C584(1.11); C589(1.11); C591(1.11)  LDD1655  [1]
 LDCM0459  CL67 HEK-293T C560(1.02)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C105(0.71)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C560(1.08)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C584(1.26); C589(1.26); C591(1.26)  LDD1668  [1]
 LDCM0472  CL79 HEK-293T C560(0.94)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C105(0.02)  LDD1678  [1]
 LDCM0478  CL84 HEK-293T C584(1.30); C589(1.30); C591(1.30)  LDD1681  [1]
 LDCM0484  CL9 HEK-293T C105(1.24)  LDD1687  [1]
 LDCM0486  CL91 HEK-293T C560(0.83)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C105(0.91)  LDD1691  [1]
 LDCM0491  CL96 HEK-293T C584(1.29); C589(1.29); C591(1.29)  LDD1694  [1]
 LDCM0022  KB02 BICR-22 C449(1.60)  LDD2266  [4]
 LDCM0023  KB03 CAL-27 C449(1.44)  LDD2703  [4]
 LDCM0024  KB05 Detroit 562 C449(1.45)  LDD3150  [4]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840