Details of the Target

General Information of Target

Target ID LDTP08852
Target Name Fibroblast growth factor receptor-like 1 (FGFRL1)
Gene Name FGFRL1
Gene ID 53834
Synonyms
FGFR5; FHFR; Fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
HTHTHSHTHSHVEGKVHQHIHYQC
Target Bioclass
Immunoglobulin
Subcellular location
Membrane
Function Has a negative effect on cell proliferation.
Uniprot ID
Q8N441
Ensemble ID
ENST00000264748.6
HGNC ID
HGNC:3693

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K154(1.13); K218(1.34); K34(3.03); K30(3.03)  LDD3494  [1]
DBIA
 Probe Info  		C406(1.03)  LDD1508  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C406(1.03)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C406(1.03)  LDD1509  [2]
 LDCM0277  AC18 HEK-293T C406(1.04)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C406(1.21)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C406(0.94)  LDD1518  [2]
 LDCM0284  AC24 HEK-293T C406(1.05)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C406(0.97)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C406(0.88)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C406(1.07)  LDD1529  [2]
 LDCM0293  AC32 HEK-293T C406(1.03)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C406(0.98)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C406(1.04)  LDD1535  [2]
 LDCM0302  AC40 HEK-293T C406(1.11)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C406(1.10)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C406(1.09)  LDD1544  [2]
 LDCM0310  AC48 HEK-293T C406(1.07)  LDD1549  [2]
 LDCM0313  AC50 HEK-293T C406(1.07)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C406(1.01)  LDD1553  [2]
 LDCM0319  AC56 HEK-293T C406(1.05)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C406(1.05)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C406(1.08)  LDD1561  [2]
 LDCM0328  AC64 HEK-293T C406(1.11)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C406(1.16)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C406(1.04)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C406(1.03)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C406(0.96)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C406(0.98)  LDD1575  [2]
 LDCM0374  CL105 HEK-293T C406(1.10)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C406(0.94)  LDD1579  [2]
 LDCM0378  CL109 HEK-293T C406(0.89)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C406(1.11)  LDD1584  [2]
 LDCM0383  CL113 HEK-293T C406(1.02)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C406(0.94)  LDD1588  [2]
 LDCM0387  CL117 HEK-293T C406(0.94)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C406(0.94)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C406(1.10)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C406(1.19)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C406(0.93)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C406(1.04)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C406(1.01)  LDD1601  [2]
 LDCM0400  CL13 HEK-293T C406(1.17)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C406(1.06)  LDD1605  [2]
 LDCM0405  CL18 HEK-293T C406(1.12)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C406(1.19)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C406(1.08)  LDD1611  [2]
 LDCM0412  CL24 HEK-293T C406(1.30)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C406(0.97)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C406(1.01)  LDD1618  [2]
 LDCM0419  CL30 HEK-293T C406(1.20)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C406(1.03)  LDD1624  [2]
 LDCM0425  CL36 HEK-293T C406(1.09)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C406(0.94)  LDD1630  [2]
 LDCM0432  CL42 HEK-293T C406(1.07)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C406(1.08)  LDD1637  [2]
 LDCM0438  CL48 HEK-293T C406(0.99)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C406(1.01)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C406(1.08)  LDD1645  [2]
 LDCM0445  CL54 HEK-293T C406(1.09)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C406(1.14)  LDD1649  [2]
 LDCM0451  CL6 HEK-293T C406(1.15)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C406(1.18)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C406(0.97)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C406(0.89)  LDD1657  [2]
 LDCM0458  CL66 HEK-293T C406(0.96)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C406(1.08)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C406(1.13)  LDD1665  [2]
 LDCM0465  CL72 HEK-293T C406(1.15)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C406(1.01)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C406(0.97)  LDD1670  [2]
 LDCM0471  CL78 HEK-293T C406(0.94)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C406(0.92)  LDD1675  [2]
 LDCM0478  CL84 HEK-293T C406(1.15)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C406(0.93)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C406(1.00)  LDD1683  [2]
 LDCM0485  CL90 HEK-293T C406(1.20)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C406(1.13)  LDD1689  [2]
 LDCM0491  CL96 HEK-293T C406(1.10)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C406(0.94)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C406(0.87)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C406(1.10)  LDD1631  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402