Details of the Target

General Information of Target

Target ID LDTP08787
Target Name Histone H2B type 3-B (H2BC26)
Gene Name H2BC26
Gene ID 128312
Synonyms
H2BU1; HIST3H2BB; Histone H2B type 3-B; H2B type 12; H2B-clustered histone 26; H2B.U histone 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q8N257
Ensemble ID
ENST00000620438.2
HGNC ID
HGNC:20514

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		N.A.  LDD0273  [1]
HHS-475
 Probe Info  		Y84(1.13)  LDD0264  [2]
HHS-465
 Probe Info  		Y84(2.95)  LDD2237  [3]
aONE
 Probe Info  		K117(0.00); K109(0.00)  LDD0002  [4]
NHS
 Probe Info  		K47(0.00); K58(0.00); K109(0.00); K6(0.00)  LDD0010  [4]
SF
 Probe Info  		K86(0.00); K35(0.00); Y84(0.00); Y41(0.00)  LDD0028  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y84(1.13)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y84(1.00)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y84(1.27)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y84(1.26)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y84(1.74)  LDD0268  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931