Details of the Target

General Information of Target

Target ID LDTP08715
Target Name CKLF-like MARVEL transmembrane domain-containing protein 4 (CMTM4)
Gene Name CMTM4
Gene ID 146223
Synonyms
CKLFSF4; CKLF-like MARVEL transmembrane domain-containing protein 4; Chemokine-like factor superfamily member 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
Target Bioclass
Cytokine and receptor
Family
Chemokine-like factor family
Subcellular location
Membrane
Function
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Uniprot ID
Q8IZR5
Ensemble ID
ENST00000330687.8
HGNC ID
HGNC:19175

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y187(8.87)  LDD3495  [1]
DBIA
 Probe Info  		C45(1.02)  LDD1507  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C45(1.02)  LDD1507  [2]
 LDCM0237  AC12 HEK-293T C45(0.96)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C45(1.10)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C45(1.32)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C45(0.86)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C45(0.93)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C45(1.15)  LDD1524  [2]
 LDCM0288  AC28 HEK-293T C45(1.03)  LDD1527  [2]
 LDCM0292  AC31 HEK-293T C45(0.95)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C45(0.94)  LDD1533  [2]
 LDCM0297  AC36 HEK-293T C45(1.05)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C45(1.05)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C45(1.05)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C45(1.14)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C45(1.04)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C45(1.07)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C45(1.17)  LDD1550  [2]
 LDCM0315  AC52 HEK-293T C45(0.95)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C45(1.00)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C45(1.02)  LDD1559  [2]
 LDCM0324  AC60 HEK-293T C45(1.02)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C45(1.03)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C45(1.08)  LDD1568  [2]
 LDCM0356  AKOS034007680 HEK-293T C45(1.22)  LDD1570  [2]
 LDCM0371  CL102 HEK-293T C45(1.21)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C45(1.00)  LDD1576  [2]
 LDCM0375  CL106 HEK-293T C45(0.99)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C45(0.96)  LDD1580  [2]
 LDCM0379  CL11 HEK-293T C45(1.13)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C45(1.20)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C45(1.02)  LDD1585  [2]
 LDCM0384  CL114 HEK-293T C45(1.29)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C45(0.97)  LDD1589  [2]
 LDCM0388  CL118 HEK-293T C45(1.17)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C45(1.07)  LDD1593  [2]
 LDCM0393  CL122 HEK-293T C45(1.19)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C45(0.96)  LDD1598  [2]
 LDCM0397  CL126 HEK-293T C45(1.15)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C45(1.09)  LDD1602  [2]
 LDCM0401  CL14 HEK-293T C45(1.12)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C45(1.11)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C45(1.18)  LDD1608  [2]
 LDCM0407  CL2 HEK-293T C45(1.08)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C45(1.13)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C45(1.13)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C45(1.07)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C45(1.00)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C45(0.96)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C45(0.88)  LDD1622  [2]
 LDCM0421  CL32 HEK-293T C45(0.97)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C45(1.27)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C45(0.93)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C45(1.08)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C45(0.97)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C45(1.07)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C45(1.08)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C45(1.24)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C45(1.35)  LDD1647  [2]
 LDCM0447  CL56 HEK-293T C45(1.06)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C45(1.17)  LDD1653  [2]
 LDCM0454  CL62 HEK-293T C45(1.10)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C45(1.02)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C45(1.16)  LDD1660  [2]
 LDCM0460  CL68 HEK-293T C45(1.05)  LDD1663  [2]
 LDCM0464  CL71 HEK-293T C45(1.23)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C45(1.12)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C45(1.31)  LDD1673  [2]
 LDCM0473  CL8 HEK-293T C45(1.01)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C45(1.07)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C45(1.13)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C45(1.08)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C45(0.99)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C45(1.08)  LDD1686  [2]
 LDCM0487  CL92 HEK-293T C45(0.97)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C45(1.45)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C45(1.05)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C45(0.87)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C45(1.04)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C45(0.98)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C45(1.13)  LDD1631  [2]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402