Details of the Target

General Information of Target

Target ID LDTP08500
Target Name Nostrin (NOSTRIN)
Gene Name NOSTRIN
Gene ID 115677
Synonyms
Nostrin; BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRDPLTDCPYNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKAL
QNTRKSCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVE
KTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKL
EKEDENYYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQT
LTTCHTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKS
LLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLE
ANSYKLSSMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASS
GGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEGGWWFGSL
NGKKGHFPAAYVEELPSNAGNTATKA
Target Bioclass
Other
Subcellular location
Nucleus; Cell membrane
Function Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Uniprot ID
Q8IVI9
Ensemble ID
ENST00000317647.12
HGNC ID
HGNC:20203

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.Q30TfsTer15 .
CASKI SNV: p.A251T .
L428 SNV: p.R410T .
MFE319 SNV: p.D319G .
NCIH1703 SNV: p.R389S .
OVK18 SNV: p.L125F .
RPMI8226 SNV: p.S363F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C8(0.83)  LDD3342  [1]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		16.05  LDD0472  [2]
FFF probe3
 Probe Info  		20.00  LDD0465  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-549 C8(3.54)  LDD2260  [1]
 LDCM0023  KB03 A-549 C8(3.77)  LDD2677  [1]
 LDCM0024  KB05 NCI-H1155 C8(0.83)  LDD3342  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nitric oxide synthase 3 (NOS3) NOS family P29474
Fibroblast growth factor receptor 1 (FGFR1) Tyr protein kinase family P11362
Dynamin-1 (DNM1) Dynamin/Fzo/YdjA family Q05193
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melanoma-associated antigen 6 (MAGEA6) . P43360

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.