Details of the Target

General Information of Target

Target ID LDTP08480
Target Name Protein HID1 (HID1)
Gene Name HID1
Gene ID 283987
Synonyms
C17orf28; DMC1; Protein HID1; Down-regulated in multiple cancers 1; HID1 domain-containing protein; Protein hid-1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVRE
ESPSNLATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWS
TVPGAGRGGQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSC
EYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCST
ENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSA
SPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPN
STKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILFFLNDARADQSRVGLMH
IGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPL
FDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSAAQNHHLVFFLLEVFNNII
QYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRRRRTPEPLSRTGSQEGTSME
GSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPEPQQSLEDGSPAKGEPS
QAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDE
SEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTDV
KLFEIQRV
Target Bioclass
Other
Family
Hid-1 family
Subcellular location
Cytoplasm
Function May play an important role in the development of cancers in a broad range of tissues.
Uniprot ID
Q8IV36
Ensemble ID
ENST00000425042.7
HGNC ID
HGNC:15736

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.P140L DBIA    Probe Info 
CCLP1 SNV: p.R103H .
HELA SNV: p.D135E .
JURKAT SNV: p.R334H .
LNCaP clone FGC SNV: p.M761I .
MELJUSO SNV: p.H740P .
MEWO Substitution: p.MG1_?2 .
MOLT4 SNV: p.V437A .
NCIH2172 SNV: p.A125E .
P31FUJ SNV: p.S670P .
PANC1 SNV: p.P222S .
SKMEL24 SNV: p.W184Ter .
TC71 SNV: p.E709D .
TOV21G SNV: p.E54Ter; p.H458N .
UMUC3 SNV: p.E722Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C70(1.67)  LDD3314  [1]
IA-alkyne
 Probe Info  		C70(0.00); C712(0.00); C85(0.00); C97(0.00)  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
NAIA_5
 Probe Info  		C70(0.00); C483(0.00); C85(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C85(0.98)  LDD1507  [5]
 LDCM0276  AC17 HEK-293T C85(1.00)  LDD1515  [5]
 LDCM0281  AC21 HEK-293T C85(1.07)  LDD1520  [5]
 LDCM0284  AC24 HEK-293T C85(0.82)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C85(0.92)  LDD1524  [5]
 LDCM0289  AC29 HEK-293T C85(1.18)  LDD1528  [5]
 LDCM0293  AC32 HEK-293T C85(0.91)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C85(0.99)  LDD1533  [5]
 LDCM0298  AC37 HEK-293T C85(1.32)  LDD1537  [5]
 LDCM0302  AC40 HEK-293T C85(1.02)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C85(1.06)  LDD1542  [5]
 LDCM0307  AC45 HEK-293T C85(1.09)  LDD1546  [5]
 LDCM0310  AC48 HEK-293T C85(0.97)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C85(1.12)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C85(1.22)  LDD1551  [5]
 LDCM0316  AC53 HEK-293T C85(0.92)  LDD1555  [5]
 LDCM0319  AC56 HEK-293T C85(0.90)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C85(1.00)  LDD1559  [5]
 LDCM0325  AC61 HEK-293T C85(1.00)  LDD1564  [5]
 LDCM0328  AC64 HEK-293T C85(1.15)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C85(0.98)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C85(0.78)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C85(1.24)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C85(1.02)  LDD1514  [5]
 LDCM0632  CL-Sc Hep-G2 C85(1.21); C712(0.71); C85(0.19)  LDD2227  [4]
 LDCM0390  CL12 HEK-293T C85(1.44)  LDD1594  [5]
 LDCM0404  CL17 HEK-293T C85(0.77)  LDD1608  [5]
 LDCM0409  CL21 HEK-293T C85(1.05)  LDD1613  [5]
 LDCM0412  CL24 HEK-293T C85(1.27)  LDD1616  [5]
 LDCM0417  CL29 HEK-293T C85(1.12)  LDD1621  [5]
 LDCM0422  CL33 HEK-293T C85(1.09)  LDD1626  [5]
 LDCM0425  CL36 HEK-293T C85(1.22)  LDD1629  [5]
 LDCM0431  CL41 HEK-293T C85(1.21)  LDD1635  [5]
 LDCM0435  CL45 HEK-293T C85(0.97)  LDD1639  [5]
 LDCM0438  CL48 HEK-293T C85(1.02)  LDD1642  [5]
 LDCM0440  CL5 HEK-293T C85(1.04)  LDD1644  [5]
 LDCM0444  CL53 HEK-293T C85(1.22)  LDD1647  [5]
 LDCM0448  CL57 HEK-293T C85(0.88)  LDD1651  [5]
 LDCM0452  CL60 HEK-293T C85(1.18)  LDD1655  [5]
 LDCM0457  CL65 HEK-293T C85(1.17)  LDD1660  [5]
 LDCM0461  CL69 HEK-293T C85(1.05)  LDD1664  [5]
 LDCM0465  CL72 HEK-293T C85(0.97)  LDD1668  [5]
 LDCM0470  CL77 HEK-293T C85(1.45)  LDD1673  [5]
 LDCM0475  CL81 HEK-293T C85(0.80)  LDD1678  [5]
 LDCM0478  CL84 HEK-293T C85(1.01)  LDD1681  [5]
 LDCM0483  CL89 HEK-293T C85(0.87)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C85(0.85)  LDD1687  [5]
 LDCM0488  CL93 HEK-293T C85(1.24)  LDD1691  [5]
 LDCM0491  CL96 HEK-293T C85(0.80)  LDD1694  [5]
 LDCM0022  KB02 HEK-293T C85(0.92)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C85(0.93)  LDD1497  [5]
 LDCM0024  KB05 IGR37 C70(1.67)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) Inositol 1,4,5-trisphosphate 5-phosphatase family O15357
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cold shock domain-containing protein E1 (CSDE1) . O75534
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquitin-like protein 5 (UBL5) . Q9BZL1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402