Details of the Target

General Information of Target

Target ID LDTP08414
Target Name C2 domain-containing protein 5 (C2CD5)
Gene Name C2CD5
Gene ID 9847
Synonyms
CDP138; KIAA0528; C2 domain-containing protein 5; C2 domain-containing phosphoprotein of 138 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEV
DDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAATVISGWFPIYDTIHGIRG
EINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVIIHGFVEELVVNEDPEYQWID
RIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIG
TACTLDKLSSPAAFLPACNSPSKEMKEIPFNEDPNPNTHSSGPSTPLKNQTYSFSPSKSY
SRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPPGF
LVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSI
CEEVCILSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHL
TYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLLPF
MEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGK
TPNDGSYEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSE
SSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNWTS
EIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLP
EDELIQVTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPF
PPAKAMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFI
RETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQC
LINVSGDAVVFVRESDLEVVSSQQPTTNCQSSCTEGEVTT
Target Bioclass
Other
Subcellular location
Cytoplasmic vesicle membrane
Function
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Uniprot ID
Q86YS7
Ensemble ID
ENST00000333957.8
HGNC ID
HGNC:29062

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K617(7.69)  LDD0277  [2]
DBIA
 Probe Info  		C998(1.99)  LDD3310  [3]
AHL-Pu-1
 Probe Info  		C867(2.40)  LDD0168  [4]
N1
 Probe Info  		M199(0.00); S200(0.00)  LDD0245  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C831(0.00); C449(0.00); C512(0.00); C751(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C148(0.00); C449(0.00); C751(0.00); C867(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C148(0.00); C449(0.00); C512(0.00); C867(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		C449(0.00); 0.00  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		C989(0.00); C993(0.00); C867(0.00)  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0005  [9]
Phosphinate-6
 Probe Info  		C449(0.00); C867(0.00)  LDD0018  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C867(2.40)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C867(2.47); C449(2.06)  LDD0169  [4]
 LDCM0632  CL-Sc Hep-G2 C831(0.46)  LDD2227  [7]
 LDCM0634  CY-0357 Hep-G2 C449(0.87)  LDD2228  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C867(1.26)  LDD1702  [12]
 LDCM0572  Fragment10 Ramos C449(1.96)  LDD2189  [13]
 LDCM0574  Fragment12 Ramos C449(0.87)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C449(0.55)  LDD2192  [13]
 LDCM0579  Fragment20 Ramos C449(1.01)  LDD2194  [13]
 LDCM0582  Fragment23 Ramos C449(0.56)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C449(0.72)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C449(0.82)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C449(0.52)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C449(0.92)  LDD2200  [13]
 LDCM0468  Fragment33 Ramos C449(0.72)  LDD2202  [13]
 LDCM0596  Fragment38 Ramos C449(0.30)  LDD2203  [13]
 LDCM0022  KB02 T cell-activated C867(6.65)  LDD1704  [14]
 LDCM0023  KB03 MDA-MB-231 C867(2.15)  LDD1701  [12]
 LDCM0024  KB05 COLO792 C998(1.99)  LDD3310  [3]
 LDCM0131  RA190 MM1.R C989(1.08); C993(1.08)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.