Details of the Target

General Information of Target

Target ID LDTP08336
Target Name F-BAR and double SH3 domains protein 1 (FCHSD1)
Gene Name FCHSD1
Gene ID 89848
Synonyms
F-BAR and double SH3 domains protein 1; Protein nervous wreck 2; NWK2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL
AGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE
QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIF
HSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSE
LSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQ
FQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQA
SEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQ
ERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQ
AGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDN
PCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFP
SLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFL
DMMAPRLRPMRPPPPPPAKAPDPGHPDPLT
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Promotes actin polymerization mediated by SNX9 and WASL.
Uniprot ID
Q86WN1
Ensemble ID
ENST00000435817.7
HGNC ID
HGNC:25463

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EOL1 SNV: p.P649A .
HCT116 SNV: p.W494Ter .
HT Deletion: p.P611QfsTer52 .
MEWO SNV: p.L25F DBIA    Probe Info 
NALM6 SNV: p.V319M .
TOV21G SNV: p.Q30H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K66(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C471(1.42)  LDD3314  [2]
IA-alkyne
 Probe Info  		C449(19.63)  LDD1707  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C310(0.96)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C88(1.18)  LDD1512  [5]
 LDCM0280  AC20 HEK-293T C310(0.83)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C88(0.98)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C88(1.02)  LDD1521  [5]
 LDCM0288  AC28 HEK-293T C310(0.98)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C88(0.95)  LDD1528  [5]
 LDCM0291  AC30 HEK-293T C88(1.10)  LDD1530  [5]
 LDCM0297  AC36 HEK-293T C310(1.06)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C88(1.00)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C88(0.96)  LDD1538  [5]
 LDCM0301  AC4 HEK-293T C310(0.90)  LDD1540  [5]
 LDCM0306  AC44 HEK-293T C310(0.89)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C88(0.97)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C88(0.88)  LDD1547  [5]
 LDCM0312  AC5 HEK-293T C88(1.04)  LDD1551  [5]
 LDCM0315  AC52 HEK-293T C310(1.34)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C88(1.07)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C88(0.86)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C88(1.04)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C310(1.01)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C88(0.93)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C88(0.89)  LDD1565  [5]
 LDCM0248  AKOS034007472 HEK-293T C88(1.13)  LDD1511  [5]
 LDCM0367  CL1 HEK-293T C88(1.05)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C88(0.95)  LDD1572  [5]
 LDCM0370  CL101 HEK-293T C88(1.07)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C88(0.91)  LDD1576  [5]
 LDCM0374  CL105 HEK-293T C88(0.97)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C88(0.98)  LDD1580  [5]
 LDCM0378  CL109 HEK-293T C88(0.99)  LDD1582  [5]
 LDCM0381  CL111 HEK-293T C88(0.94)  LDD1585  [5]
 LDCM0383  CL113 HEK-293T C88(1.13)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C88(0.97)  LDD1589  [5]
 LDCM0387  CL117 HEK-293T C88(0.98)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C88(0.94)  LDD1593  [5]
 LDCM0392  CL121 HEK-293T C88(1.05)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C88(0.89)  LDD1598  [5]
 LDCM0396  CL125 HEK-293T C88(0.98)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C88(0.92)  LDD1602  [5]
 LDCM0400  CL13 HEK-293T C88(1.05)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C88(0.87)  LDD1606  [5]
 LDCM0408  CL20 HEK-293T C310(1.17)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C88(1.02)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C88(1.00)  LDD1614  [5]
 LDCM0413  CL25 HEK-293T C88(0.88)  LDD1617  [5]
 LDCM0415  CL27 HEK-293T C88(0.98)  LDD1619  [5]
 LDCM0418  CL3 HEK-293T C88(1.04)  LDD1622  [5]
 LDCM0421  CL32 HEK-293T C310(1.01)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C88(0.99)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C88(0.97)  LDD1627  [5]
 LDCM0426  CL37 HEK-293T C88(0.93)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C88(0.97)  LDD1632  [5]
 LDCM0434  CL44 HEK-293T C310(1.14)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C88(1.11)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C88(1.13)  LDD1640  [5]
 LDCM0439  CL49 HEK-293T C88(1.13)  LDD1643  [5]
 LDCM0447  CL56 HEK-293T C310(1.10)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C88(0.98)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C88(1.10)  LDD1652  [5]
 LDCM0453  CL61 HEK-293T C88(1.13)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C88(0.93)  LDD1658  [5]
 LDCM0460  CL68 HEK-293T C310(1.06)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C88(1.48)  LDD1664  [5]
 LDCM0463  CL70 HEK-293T C88(1.20)  LDD1666  [5]
 LDCM0466  CL73 HEK-293T C88(1.10)  LDD1669  [5]
 LDCM0473  CL8 HEK-293T C310(0.89)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C310(0.95)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C88(0.95)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C88(1.08)  LDD1679  [5]
 LDCM0479  CL85 HEK-293T C88(1.14)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C88(0.90)  LDD1684  [5]
 LDCM0484  CL9 HEK-293T C88(0.98)  LDD1687  [5]
 LDCM0487  CL92 HEK-293T C310(0.94)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C88(1.05)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C88(0.90)  LDD1692  [5]
 LDCM0492  CL97 HEK-293T C88(1.04)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C88(0.88)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C88(0.95)  LDD1698  [5]
 LDCM0573  Fragment11 Ramos C88(0.09)  LDD2190  [6]
 LDCM0576  Fragment14 Ramos C88(0.13)  LDD2193  [6]
 LDCM0586  Fragment28 Ramos C88(1.19)  LDD2198  [6]
 LDCM0468  Fragment33 HEK-293T C88(1.01)  LDD1671  [5]
 LDCM0566  Fragment4 Ramos C88(0.76)  LDD2184  [6]
 LDCM0569  Fragment7 Ramos C88(0.11)  LDD2186  [6]
 LDCM0022  KB02 T cell C449(19.63)  LDD1707  [3]
 LDCM0023  KB03 Ramos C88(0.83)  LDD2183  [6]
 LDCM0024  KB05 IGR37 C471(1.42)  LDD3314  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578