Details of the Target

General Information of Target

Target ID LDTP08233
Target Name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)
Gene Name MAGI2
Gene ID 9863
Synonyms
ACVRINP1; AIP1; KIAA0705; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH
LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY
VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA
PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG
SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS
SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK
PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP
QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE
STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD
GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP
QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR
EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD
KLPSVLKPGASAASR
Target Bioclass
Transporter and channel
Family
MAGUK family
Subcellular location
Cytoplasm
Function
Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis.
Uniprot ID
Q86UL8
Ensemble ID
ENST00000354212.9
HGNC ID
HGNC:18957

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.R109S .
CAL51 SNV: p.A75V .
CCK81 SNV: p.Q1116Ter .
CFPAC1 Deletion: p.R115DfsTer59 .
DU145 SNV: p.H883Y .
EFO27 SNV: p.R1316H .
HCC15 SNV: p.S1135T .
KYSE410 SNV: p.P868L .
KYSE510 SNV: p.M1205I .
L428 SNV: p.E1403K .
LN18 SNV: p.K667Ter .
MDAMB436 Deletion: p.N503_E517delinsK .
MEWO SNV: p.P42L;p.W308Ter
Substitution: p.L793F		 .
NCIH1993 SNV: p.A528S .
NCIH82 SNV: p.S1454R .
SNU1 SNV: p.A263V .
TE10 SNV: p.P638H .
TFK1 SNV: p.T624A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1378(1.44)  LDD3369  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C140(1.14)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C1303(0.84)  LDD1512  [2]
 LDCM0280  AC20 HEK-293T C140(0.98)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C1303(0.93)  LDD1521  [2]
 LDCM0288  AC28 HEK-293T C140(1.05)  LDD1527  [2]
 LDCM0291  AC30 HEK-293T C1303(0.91)  LDD1530  [2]
 LDCM0297  AC36 HEK-293T C140(0.98)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C1303(0.94)  LDD1538  [2]
 LDCM0301  AC4 HEK-293T C140(1.04)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C140(1.07)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C1303(0.90)  LDD1547  [2]
 LDCM0315  AC52 HEK-293T C140(1.06)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C1303(0.97)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C1303(0.97)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C140(1.04)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C1303(0.96)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C1303(1.21)  LDD1572  [2]
 LDCM0408  CL20 HEK-293T C140(1.18)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C1303(0.98)  LDD1614  [2]
 LDCM0421  CL32 HEK-293T C140(0.95)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C1303(1.06)  LDD1627  [2]
 LDCM0434  CL44 HEK-293T C140(0.96)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C1303(1.16)  LDD1640  [2]
 LDCM0447  CL56 HEK-293T C140(1.07)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C1303(0.96)  LDD1652  [2]
 LDCM0460  CL68 HEK-293T C140(0.99)  LDD1663  [2]
 LDCM0463  CL70 HEK-293T C1303(1.13)  LDD1666  [2]
 LDCM0473  CL8 HEK-293T C140(1.10)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C140(1.02)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C1303(0.96)  LDD1679  [2]
 LDCM0487  CL92 HEK-293T C140(1.12)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C1303(1.04)  LDD1692  [2]
 LDCM0022  KB02 A101D C1378(2.70)  LDD2250  [1]
 LDCM0023  KB03 A101D C1378(1.87)  LDD2667  [1]
 LDCM0024  KB05 OAW-42 C1378(1.44)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402