Details of the Target

General Information of Target

Target ID LDTP08137
Target Name Solute carrier family 35 member E3 (SLC35E3)
Gene Name SLC35E3
Gene ID 55508
Synonyms
BLOV1; Solute carrier family 35 member E3; Bladder cancer-overexpressed gene 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTF
CYQKTFSTRIQLTLIPITLGVILNSYYDVKFNFLGMVFAALGVLVTSLYQVWVGAKQHEL
QVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALLMVLLSGVIAFMVNLS
IYWIIGNTSPVTYNMFGHFKFCITLFGGYVLFKDPLSINQALGILCTLFGILAYTHFKLS
EQEGSRSKLAQRP
Target Bioclass
Transporter and channel
Family
TPT transporter family, SLC35E subfamily
Subcellular location
Membrane
Function Putative transporter.
Uniprot ID
Q7Z769
Ensemble ID
ENST00000398004.4
HGNC ID
HGNC:20864

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K308(1.24)  LDD0277  [1]
DBIA
 Probe Info  		C121(4.12)  LDD3403  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C121(1.12)  LDD1507  [4]
 LDCM0276  AC17 HEK-293T C121(1.14)  LDD1515  [4]
 LDCM0284  AC24 HEK-293T C121(0.96)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C121(1.07)  LDD1524  [4]
 LDCM0293  AC32 HEK-293T C121(0.89)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C121(1.10)  LDD1533  [4]
 LDCM0302  AC40 HEK-293T C121(1.07)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C121(1.10)  LDD1542  [4]
 LDCM0310  AC48 HEK-293T C121(1.17)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C121(1.19)  LDD1550  [4]
 LDCM0319  AC56 HEK-293T C121(1.13)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C121(1.21)  LDD1559  [4]
 LDCM0328  AC64 HEK-293T C121(1.04)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C121(1.16)  LDD1569  [4]
 LDCM0356  AKOS034007680 HEK-293T C121(1.15)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C121(1.12)  LDD1514  [4]
 LDCM0371  CL102 HEK-293T C121(1.00)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C121(0.92)  LDD1576  [4]
 LDCM0375  CL106 HEK-293T C121(1.09)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C121(0.93)  LDD1580  [4]
 LDCM0380  CL110 HEK-293T C121(1.14)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C121(1.14)  LDD1585  [4]
 LDCM0384  CL114 HEK-293T C121(0.95)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C121(1.03)  LDD1589  [4]
 LDCM0388  CL118 HEK-293T C121(1.16)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C121(1.07)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C121(1.18)  LDD1594  [4]
 LDCM0393  CL122 HEK-293T C121(1.05)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C121(1.30)  LDD1598  [4]
 LDCM0397  CL126 HEK-293T C121(1.21)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C121(1.04)  LDD1602  [4]
 LDCM0401  CL14 HEK-293T C121(1.08)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C121(1.07)  LDD1606  [4]
 LDCM0404  CL17 HEK-293T C121(1.10)  LDD1608  [4]
 LDCM0407  CL2 HEK-293T C121(1.02)  LDD1611  [4]
 LDCM0412  CL24 HEK-293T C121(1.18)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C121(1.24)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C121(0.94)  LDD1619  [4]
 LDCM0417  CL29 HEK-293T C121(1.13)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C121(1.18)  LDD1622  [4]
 LDCM0425  CL36 HEK-293T C121(1.41)  LDD1629  [4]
 LDCM0428  CL39 HEK-293T C121(1.03)  LDD1632  [4]
 LDCM0431  CL41 HEK-293T C121(1.11)  LDD1635  [4]
 LDCM0438  CL48 HEK-293T C121(1.47)  LDD1642  [4]
 LDCM0440  CL5 HEK-293T C121(1.14)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C121(0.97)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C121(1.13)  LDD1647  [4]
 LDCM0452  CL60 HEK-293T C121(1.17)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C121(1.22)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C121(0.99)  LDD1658  [4]
 LDCM0457  CL65 HEK-293T C121(1.18)  LDD1660  [4]
 LDCM0465  CL72 HEK-293T C121(1.29)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C121(1.07)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C121(1.13)  LDD1673  [4]
 LDCM0478  CL84 HEK-293T C121(1.15)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C121(1.20)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C121(1.06)  LDD1684  [4]
 LDCM0483  CL89 HEK-293T C121(1.18)  LDD1686  [4]
 LDCM0491  CL96 HEK-293T C121(1.40)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C121(1.14)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C121(1.00)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C121(0.98)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C121(0.97)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C121(1.10)  LDD1631  [4]
 LDCM0022  KB02 697 C121(2.58)  LDD2245  [2]
 LDCM0023  KB03 697 C121(3.87)  LDD2662  [2]
 LDCM0024  KB05 Reh C121(4.12)  LDD3403  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) Chondroitin N-acetylgalactosaminyltransferase family Q8N6G5
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 234 (TMEM234) TMEM234 family Q8WY98
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Adiponectin (ADIPOQ) . Q15848
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Probable G-protein coupled receptor 25 (GPR25) G-protein coupled receptor 1 family O00155
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Alpha-tocopherol transfer protein (TTPA) . P49638
Bcl-2-interacting killer (BIK) . Q13323
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402