Details of the Target

General Information of Target

Target ID LDTP07976
Target Name Rab11 family-interacting protein 2 (RAB11FIP2)
Gene Name RAB11FIP2
Gene ID 22841
Synonyms
KIAA0941; Rab11 family-interacting protein 2; Rab11-FIP2; NRip11
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVW
KEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWF
RLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTF
SDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEK
LKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQ
NDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLF
ERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPS
SSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDY
IDNLLVRVMEETPSILRVPYEPSRKAGKFSNS
Target Bioclass
Other
Subcellular location
Cell projection, phagocytic cup
Function
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
Uniprot ID
Q7L804
Ensemble ID
ENST00000355624.8
HGNC ID
HGNC:29152

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P189Q .
HEC1 SNV: p.A102T .
HEC1B SNV: p.A102T .
HT1197 Substitution: p.G298V .
HT3 SNV: p.L154I .
IGROV1 Insertion: p.Q313PfsTer14 .
IPC298 SNV: p.T445I .
NCIH146 SNV: p.R413M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K470(8.33)  LDD0274  [1]
AHL-Pu-1
 Probe Info  		C296(2.08)  LDD0169  [2]
DBIA
 Probe Info  		C296(1.02)  LDD1509  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C296(2.08)  LDD0169  [2]
 LDCM0226  AC11 HEK-293T C296(1.02)  LDD1509  [3]
 LDCM0278  AC19 HEK-293T C296(1.37)  LDD1517  [3]
 LDCM0287  AC27 HEK-293T C296(1.35)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C296(1.10)  LDD1529  [3]
 LDCM0296  AC35 HEK-293T C296(1.14)  LDD1535  [3]
 LDCM0305  AC43 HEK-293T C296(1.13)  LDD1544  [3]
 LDCM0314  AC51 HEK-293T C296(1.16)  LDD1553  [3]
 LDCM0322  AC59 HEK-293T C296(1.03)  LDD1561  [3]
 LDCM0369  CL100 HEK-293T C384(1.06)  LDD1573  [3]
 LDCM0372  CL103 HEK-293T C384(1.00)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C384(0.98)  LDD1577  [3]
 LDCM0376  CL107 HEK-293T C384(0.95)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C384(0.99)  LDD1581  [3]
 LDCM0381  CL111 HEK-293T C384(0.98)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C384(1.04)  LDD1586  [3]
 LDCM0385  CL115 HEK-293T C384(1.01)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C384(1.03)  LDD1590  [3]
 LDCM0389  CL119 HEK-293T C384(0.98)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C384(1.07)  LDD1595  [3]
 LDCM0394  CL123 HEK-293T C384(0.98)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C384(1.04)  LDD1599  [3]
 LDCM0398  CL127 HEK-293T C384(1.03)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C384(1.02)  LDD1603  [3]
 LDCM0402  CL15 HEK-293T C384(1.04)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C384(1.08)  LDD1607  [3]
 LDCM0406  CL19 HEK-293T C296(1.08)  LDD1610  [3]
 LDCM0415  CL27 HEK-293T C384(1.01)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C384(0.89)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C384(1.19)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C296(1.22)  LDD1624  [3]
 LDCM0428  CL39 HEK-293T C384(1.02)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C384(1.27)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C384(0.99)  LDD1634  [3]
 LDCM0433  CL43 HEK-293T C296(1.05)  LDD1637  [3]
 LDCM0443  CL52 HEK-293T C384(1.04)  LDD1646  [3]
 LDCM0446  CL55 HEK-293T C296(1.24)  LDD1649  [3]
 LDCM0455  CL63 HEK-293T C384(1.05)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C384(1.01)  LDD1659  [3]
 LDCM0459  CL67 HEK-293T C296(1.03)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C296(1.19)  LDD1665  [3]
 LDCM0469  CL76 HEK-293T C384(0.92)  LDD1672  [3]
 LDCM0472  CL79 HEK-293T C296(1.11)  LDD1675  [3]
 LDCM0481  CL87 HEK-293T C384(0.94)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C384(1.16)  LDD1685  [3]
 LDCM0486  CL91 HEK-293T C296(0.37)  LDD1689  [3]
 LDCM0494  CL99 HEK-293T C384(1.08)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C384(0.98)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C384(1.07)  LDD1671  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-11A (RAB11A) Rab family P62491
Ras-related protein Rab-11B (RAB11B) Rab family Q15907
Ras-related protein Rab-25 (RAB25) Rab family P57735
F-box only protein 17 (FBXO17) . Q96EF6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Heat shock factor 2-binding protein (HSF2BP) . O75031
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Rab11 family-interacting protein 2 (RAB11FIP2) . Q7L804

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019