Details of the Target

General Information of Target

Target ID LDTP07971
Target Name G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
Gene Name G2E3
Gene ID 55632
Synonyms
KIAA1333; G2/M phase-specific E3 ubiquitin-protein ligase; EC 2.3.2.26; G2/M phase-specific HECT-type E3 ubiquitin transferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNESKPGDSQNLACVFCRKHDDCPNKYGEKKTKEKWNLTVHYYCLLMSSGIWQRGKEEEG
VYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNF
ASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAI
NAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRC
KEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKK
HVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKK
TKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHL
ENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPE
NTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLV
KDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFT
VHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDF
PVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
Target Bioclass
Enzyme
Subcellular location
Nucleus, nucleolus
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
Uniprot ID
Q7L622
Ensemble ID
ENST00000206595.11
HGNC ID
HGNC:20338

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C666(0.91); C669(0.91)  LDD1094  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C666(0.91); C669(0.91)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C666(0.81); C669(0.81)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C666(0.88); C669(0.88)  LDD1116  [1]
 LDCM0259  AC14 PaTu 8988t C666(1.12); C669(1.12)  LDD1138  [1]
 LDCM0270  AC15 PaTu 8988t C666(0.87); C669(0.87)  LDD1149  [1]
 LDCM0296  AC35 PaTu 8988t C666(0.86); C669(0.86)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C666(0.59); C669(0.59)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C666(0.72); C669(0.72)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C666(0.64); C669(0.64)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C666(0.66); C669(0.66)  LDD1179  [1]
 LDCM0302  AC40 PaTu 8988t C666(0.58); C669(0.58)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C666(0.63); C669(0.63)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C666(0.67); C669(0.67)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C666(0.62); C669(0.62)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C666(0.73); C669(0.73)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C666(0.74); C669(0.74)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C666(1.06); C669(1.06)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C666(1.19); C669(1.19)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C666(1.01); C669(1.01)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C666(0.97); C669(0.97)  LDD1190  [1]
 LDCM0313  AC50 PaTu 8988t C666(1.00); C669(1.00)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C666(0.86); C669(0.86)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C666(0.96); C669(0.96)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C666(1.09); C669(1.09)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C666(1.17); C669(1.17)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C666(0.96); C669(0.96)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C666(1.02); C669(1.02)  LDD1198  [1]
 LDCM0323  AC6 PaTu 8988t C666(0.86); C669(0.86)  LDD1202  [1]
 LDCM0332  AC68 PaTu 8988t C666(0.99); C669(0.99)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C666(0.87); C669(0.87)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C666(0.93); C669(0.93)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C666(0.90); C669(0.90)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C666(0.89); C669(0.89)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C666(0.99); C669(0.99)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C666(0.88); C669(0.88)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C666(0.99); C669(0.99)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C666(0.88); C669(0.88)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C666(0.91); C669(0.91)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C666(0.90); C669(0.90)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C666(0.82); C669(0.82)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C666(0.83); C669(0.83)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C666(0.85); C669(0.85)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C666(0.84); C669(0.84)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C666(0.81); C669(0.81)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C666(0.90); C669(0.90)  LDD1227  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C666(0.99); C669(0.99)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C666(0.98); C669(0.98)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C666(0.92); C669(0.92)  LDD1154  [1]
 LDCM0370  CL101 PaTu 8988t C666(0.66); C669(0.66)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C666(0.82); C669(0.82)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C666(0.95); C669(0.95)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C666(0.96); C669(0.96)  LDD1252  [1]
 LDCM0387  CL117 PaTu 8988t C666(0.68); C669(0.68)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C666(0.90); C669(0.90)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C666(0.74); C669(0.74)  LDD1268  [1]
 LDCM0391  CL120 PaTu 8988t C666(0.72); C669(0.72)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C666(0.94); C669(0.94)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C666(1.12); C669(1.12)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C666(0.94); C669(0.94)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C666(0.97); C669(0.97)  LDD1274  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Small ribosomal subunit protein uS19 (RPS15) Universal ribosomal protein uS19 family P62841
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060