Details of the Target

General Information of Target

Target ID LDTP07965
Target Name Lysophospholipase D GDPD3 (GDPD3)
Gene Name GDPD3
Gene ID 79153
Synonyms
GDE7; Lysophospholipase D GDPD3; EC 3.1.4.-; Glycerophosphodiester phosphodiesterase 7; Glycerophosphodiester phosphodiesterase domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAHRGGSGELLENTMEAME
NSMAQRSDLLELDCQLTRDRVVVVSHDENLCRQSGLNRDVGSLDFEDLPLYKEKLEVYFS
PGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIREIAGLVRRYDRNEITIWASE
KSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPFIPIPEKFFFCFLPNIINRTYFP
FSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVFWCLNEESDFEAAFSVGATGVITDY
PTALRHYLDNHGPAARTS
Target Bioclass
Enzyme
Family
Glycerophosphoryl diester phosphodiesterase family
Subcellular location
Membrane
Function
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
Uniprot ID
Q7L5L3
Ensemble ID
ENST00000406256.8
HGNC ID
HGNC:28638

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C91(0.86)  LDD0532  [1]
IA-alkyne
 Probe Info  		C91(0.00); C243(0.00)  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
NAIA_5
 Probe Info  		C91(0.00); C228(0.00); C74(0.00)  LDD2223  [4]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [5]
STS-2
 Probe Info  		N.A.  LDD0139  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C91(0.86)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C91(0.73)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C91(0.73)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C91(0.67)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C91(0.76)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C91(1.05)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C91(0.94)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C91(0.93)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C91(0.99)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C91(0.83)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C91(0.77)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C91(0.80)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C91(0.80)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C91(0.94)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C91(1.26)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C91(1.18)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C91(1.29)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C91(1.34)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C91(1.29)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C91(0.99)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C91(1.14)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C91(0.97)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C91(1.07)  LDD0612  [1]
 LDCM0323  AC6 HCT 116 C91(0.77)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C91(0.89)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C91(0.73)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C91(1.49)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C91(1.09)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C91(1.55)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C91(1.45)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C91(1.72)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C91(1.88)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C91(1.68)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C91(1.63)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C91(1.68)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C91(1.72)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C91(1.23)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C91(1.54)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C91(1.56)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C91(1.06)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C91(2.27)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C91(0.83)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C91(0.76)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C91(0.99)  LDD0592  [1]
 LDCM0632  CL-Sc Hep-G2 C91(0.68); C91(0.66)  LDD2227  [4]
 LDCM0370  CL101 HCT 116 C91(0.84)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C91(0.87)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C91(0.95)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C91(0.92)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C91(0.88)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C91(0.77)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C91(0.83)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C91(1.05)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C91(0.87)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C91(0.81)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C91(0.97)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C91(1.03)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C91(1.17)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C91(1.17)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C91(1.07)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C91(0.93)  LDD0703  [1]
 LDCM0634  CY-0357 Hep-G2 C91(1.05)  LDD2228  [4]
 LDCM0022  KB02 A2780 C91(1.67)  LDD2254  [6]
 LDCM0023  KB03 A2780 C91(1.73)  LDD2671  [6]
 LDCM0024  KB05 HMCB C91(1.48)  LDD3312  [6]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840