Details of the Target

General Information of Target

Target ID LDTP07949
Target Name Zinc finger protein 765 (ZNF765)
Gene Name ZNF765
Gene ID 91661
Synonyms
Zinc finger protein 765
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSS
TAQGNREVFHAGTSQRHESHHNGDFCFQDIDKDIHDIEFQWQEDERNGHEALMTKIKKLT
GSTERYDQNYAGNKPVKYQLGFSFHSHLPELHIFHTEEKIDNQVVKSIHDASLVSTAQRI
SCRPETHISNDYGNNFLNSSLFTQKQEVHMREKSFQCNDSGKAYNCSSLLRKHQLIHLGE
KQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECGKTFSQTYYLTCHRRLHTGEKPYK
CEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQKSYLTCHRRLHTGEKPYKCNEC
GKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRRLHTEEKPYKCNECGKTF
NQQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSS
LTYHHRLHTGQKPYKCEDCDEAFSFKSNLERHRRIYTGEKLHV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q7L2R6
Ensemble ID
ENST00000396408.8
HGNC ID
HGNC:25092

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.A177S .
HCT15 SNV: p.D89A .
HT115 SNV: p.F196V; p.E519D .
JEKO1 SNV: p.K306R .
NCIH1666 SNV: p.L32V .
OPM2 SNV: p.G295Ter .
SKN SNV: p.K384T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C372(0.96)  LDD3368  [1]
AHL-Pu-1
 Probe Info  		C344(2.07)  LDD0171  [2]
IA-alkyne
 Probe Info  		C344(2.72)  LDD0372  [2]
HHS-465
 Probe Info  		K297(0.00); K300(0.00); K325(0.00); K328(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C344(2.07)  LDD0171  [2]
 LDCM0281  AC21 HEK-293T C288(0.76)  LDD1520  [4]
 LDCM0289  AC29 HEK-293T C288(1.12)  LDD1528  [4]
 LDCM0298  AC37 HEK-293T C288(0.83)  LDD1537  [4]
 LDCM0307  AC45 HEK-293T C288(1.06)  LDD1546  [4]
 LDCM0312  AC5 HEK-293T C288(1.03)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C288(0.91)  LDD1555  [4]
 LDCM0325  AC61 HEK-293T C288(0.82)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C288(0.74)  LDD1511  [4]
 LDCM0409  CL21 HEK-293T C288(0.87)  LDD1613  [4]
 LDCM0422  CL33 HEK-293T C288(0.83)  LDD1626  [4]
 LDCM0435  CL45 HEK-293T C288(0.71)  LDD1639  [4]
 LDCM0448  CL57 HEK-293T C288(0.80)  LDD1651  [4]
 LDCM0461  CL69 HEK-293T C288(0.73)  LDD1664  [4]
 LDCM0475  CL81 HEK-293T C288(0.77)  LDD1678  [4]
 LDCM0484  CL9 HEK-293T C288(0.81)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C288(0.66)  LDD1691  [4]
 LDCM0022  KB02 HEK-293T C288(1.03)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C288(1.01)  LDD1497  [4]
 LDCM0024  KB05 OAW-28 C372(0.96)  LDD3368  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Proto-oncogene c-Rel (REL) . Q04864
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Centromere protein P (CENPP) CENP-P/CTF19 family Q6IPU0
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Protein INCA1 (INCA1) INCA family Q0VD86
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Mitochondrial coiled-coil domain protein 1 (MCCD1) . P59942
Ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2) . Q9BRT2

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402