Details of the Target

General Information of Target

Target ID LDTP07650
Target Name Methionine aminopeptidase 1D, mitochondrial (METAP1D)
Gene Name METAP1D
Gene ID 254042
Synonyms
MAP1D; Methionine aminopeptidase 1D, mitochondrial; MAP 1D; MetAP 1D; EC 3.4.11.18; Methionyl aminopeptidase type 1D, mitochondrial; Peptidase M 1D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPSGVHLLVRRGSHRIFSSPLNHIYLHKQSSSQQRRNFFFRRQRDISHSIVLPAAVSS
AHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMT
TEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVT
VYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQ
NGFQVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDA
WTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA
Target Bioclass
Enzyme
Family
Peptidase M24A family, Methionine aminopeptidase type 1 subfamily
Subcellular location
Mitochondrion
Function
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. May play a role in colon tumorigenesis. {|HAMAP-Rule:MF_03174}.
Uniprot ID
Q6UB28
Ensemble ID
ENST00000315796.5
HGNC ID
HGNC:32583
ChEMBL ID
CHEMBL3831223

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C152(2.58)  LDD0812  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C152(2.58)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C152(1.17)  LDD0813  [1]
 LDCM0226  AC11 HEK-293T C152(0.81)  LDD0824  [1]
 LDCM0237  AC12 HEK-293T C152(1.00)  LDD0835  [1]
 LDCM0259  AC14 HEK-293T C152(0.97)  LDD0857  [1]
 LDCM0270  AC15 HEK-293T C152(1.29)  LDD0868  [1]
 LDCM0279  AC2 HEK-293T C152(1.23)  LDD0877  [1]
 LDCM0290  AC3 HEK-293T C152(0.98)  LDD0888  [1]
 LDCM0301  AC4 HEK-293T C152(0.93)  LDD0899  [1]
 LDCM0312  AC5 HEK-293T C152(1.09)  LDD0910  [1]
 LDCM0323  AC6 HEK-293T C152(0.85)  LDD0921  [1]
 LDCM0334  AC7 HEK-293T C152(1.06)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C152(1.05)  LDD0943  [1]
 LDCM0248  AKOS034007472 HEK-293T C152(1.02)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C152(1.26)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C152(1.02)  LDD0873  [1]
 LDCM0369  CL100 HEK-293T C152(1.34)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C152(1.23)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C152(1.06)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C152(1.31)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C152(1.19)  LDD0971  [1]
 LDCM0403  CL16 HEK-293T C152(1.02)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C152(1.03)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C152(1.06)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C152(1.19)  LDD1004  [1]
 LDCM0408  CL20 HEK-293T C152(1.07)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C152(1.27)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C152(1.24)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C152(1.02)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C152(0.96)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C152(1.10)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C152(1.09)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C152(1.14)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C152(0.99)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C152(1.09)  LDD1015  [1]
 LDCM0419  CL30 HEK-293T C152(1.41)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C152(1.02)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C152(1.08)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C152(1.15)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C152(1.23)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C152(1.24)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C152(1.19)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C152(1.17)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C152(1.64)  LDD1026  [1]
 LDCM0430  CL40 HEK-293T C152(1.19)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C152(1.47)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C152(1.63)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C152(1.64)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C152(1.19)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C152(1.48)  LDD1033  [1]
 LDCM0486  CL91 HEK-293T C152(0.92)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C152(1.04)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C152(1.02)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C152(1.43)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C152(1.48)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C152(1.04)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C152(1.06)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C152(1.17)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C152(1.13)  LDD1092  [1]
 LDCM0427  Fragment51 HEK-293T C152(1.23)  LDD1025  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377