Details of the Target

General Information of Target

Target ID LDTP07282
Target Name Teashirt homolog 3 (TSHZ3)
Gene Name TSHZ3
Gene ID 57616
Synonyms
KIAA1474; TSH3; ZNF537; Teashirt homolog 3; Zinc finger protein 537
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQ
NSPAAEFSCHEMDSESHISETSDRMADFESGSIKNEEETKEVTVPLEDTTVSDSLEQMKA
VYNNFLSNSYWSNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVS
QSRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYR
DDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHY
QKVPLKEPVTPVAAKIIPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSNPYI
TPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMK
KGKPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAV
TDEKPKQKDKPGEEEEKCDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNG
TPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKNQTLVSPPSSQTS
PMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDGKLSPPKRATPSPCSSEVGEPIKMEASS
DGGFRSQENSPSPPRDGCKDGSPLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVN
PLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQSKKADHLDRY
FYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLR
ENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNP
QHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRT
GGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINSQIAQ
TKSPSEKMVTSSPEEDLGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEK
Q
Target Bioclass
Transcription factor
Family
Teashirt C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation.
Uniprot ID
Q63HK5
Ensemble ID
ENST00000240587.5
HGNC ID
HGNC:30700

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K44(0.15)  LDD3494  [1]
DBIA
 Probe Info  		C498(2.17)  LDD3401  [2]
IPM
 Probe Info  		C646(0.00); C498(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C801(0.88)  LDD1523  [4]
 LDCM0293  AC32 HEK-293T C801(0.80)  LDD1532  [4]
 LDCM0302  AC40 HEK-293T C801(0.90)  LDD1541  [4]
 LDCM0310  AC48 HEK-293T C801(0.92)  LDD1549  [4]
 LDCM0319  AC56 HEK-293T C801(0.92)  LDD1558  [4]
 LDCM0328  AC64 HEK-293T C801(1.34)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C801(1.01)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C801(0.85)  LDD1514  [4]
 LDCM0390  CL12 HEK-293T C801(0.99)  LDD1594  [4]
 LDCM0412  CL24 HEK-293T C801(0.97)  LDD1616  [4]
 LDCM0425  CL36 HEK-293T C801(1.03)  LDD1629  [4]
 LDCM0438  CL48 HEK-293T C801(1.01)  LDD1642  [4]
 LDCM0452  CL60 HEK-293T C801(0.98)  LDD1655  [4]
 LDCM0465  CL72 HEK-293T C801(0.96)  LDD1668  [4]
 LDCM0478  CL84 HEK-293T C801(1.02)  LDD1681  [4]
 LDCM0491  CL96 HEK-293T C801(1.06)  LDD1694  [4]
 LDCM0022  KB02 A673 C498(1.63)  LDD2261  [2]
 LDCM0023  KB03 RD C498(2.21)  LDD2984  [2]
 LDCM0024  KB05 RD C498(2.17)  LDD3401  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2) DNA repair enzymes AP/ExoA family Q9UBZ4
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein bL28m (MRPL28) Bacterial ribosomal protein bL28 family Q13084
Centrosomal protein of 63 kDa (CEP63) CEP63 family Q96MT8
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Ankyrin repeat family A protein 2 (ANKRA2) . Q9H9E1
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Heat shock factor 2-binding protein (HSF2BP) . O75031
Leucine-rich repeat-containing protein 73 (LRRC73) . Q5JTD7
Protein KASH5 (KASH5) . Q8N6L0
Sperm-associated antigen 5 (SPAG5) . Q96R06
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402