Details of the Target

General Information of Target

Target ID LDTP07270
Target Name Tetratricopeptide repeat protein 23 (TTC23)
Gene Name TTC23
Gene ID 64927
Synonyms
Tetratricopeptide repeat protein 23; TPR repeat protein 23; Cervical cancer proto-oncogene 8 protein; HCC-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREKLHLCEEKAKSYSNSHE
YKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKGLSLQAKQHAEKARQILAN
SIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEE
WIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQA
LGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVAHAAVASGRHEHHDVAEQYFQESMA
HLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYR
LLGGADLAQGNHSGARKKLKKCLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQA
SKAKVAFCTSIPQDTLLGKARPGTTAD
Target Bioclass
Other
Subcellular location
Cell projection, cilium
Function Participates positively in the ciliary Hedgehog (Hh) signaling.
Uniprot ID
Q5W5X9
Ensemble ID
ENST00000262074.8
HGNC ID
HGNC:25730

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB231 SNV: p.T444P .
SHP77 SNV: p.V275F .
SW1271 SNV: p.R225S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C173(0.82)  LDD2227  [1]
DBIA
 Probe Info  		C321(0.94)  LDD1508  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C321(0.94)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C321(1.18)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C321(0.82)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C321(1.23)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C321(0.90)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C321(1.02)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C321(1.10)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C321(0.84)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C321(0.76)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C321(0.98)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C321(1.30)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C321(0.71)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C321(0.94)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C321(0.79)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C321(0.90)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C321(1.30)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C321(0.88)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C321(1.04)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C321(0.74)  LDD1540  [2]
 LDCM0304  AC42 HEK-293T C321(1.43)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C321(1.02)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C321(1.19)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C321(1.10)  LDD1548  [2]
 LDCM0313  AC50 HEK-293T C321(0.99)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C321(1.13)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C321(0.59)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C321(1.28)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C321(0.92)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C321(1.36)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C321(1.01)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C321(1.11)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C321(1.49)  LDD1568  [2]
 LDCM0632  CL-Sc Hep-G2 C173(0.82)  LDD2227  [1]
 LDCM0379  CL11 HEK-293T C321(1.33)  LDD1583  [2]
 LDCM0405  CL18 HEK-293T C321(0.87)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C321(1.16)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C321(0.67)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C321(0.87)  LDD1615  [2]
 LDCM0419  CL30 HEK-293T C321(0.91)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C321(1.25)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C321(0.70)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C321(1.41)  LDD1628  [2]
 LDCM0432  CL42 HEK-293T C321(0.87)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C321(1.12)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C321(0.86)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C321(1.27)  LDD1641  [2]
 LDCM0445  CL54 HEK-293T C321(0.90)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C321(1.34)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C321(0.83)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C321(1.24)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C321(0.85)  LDD1654  [2]
 LDCM0458  CL66 HEK-293T C321(0.92)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C321(1.56)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C321(0.91)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C321(1.41)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C321(1.02)  LDD1667  [2]
 LDCM0471  CL78 HEK-293T C321(0.99)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C321(0.98)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C321(0.57)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C321(0.65)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C321(1.20)  LDD1680  [2]
 LDCM0485  CL90 HEK-293T C321(0.96)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C321(1.19)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C321(0.70)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C321(2.07)  LDD1693  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-3' exoribonuclease 2 (XRN2) 5'-3' exonuclease family Q9H0D6
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Adenylate cyclase type 4 (ADCY4) Adenylyl cyclase class-4/guanylyl cyclase family Q8NFM4
DNA-directed RNA polymerase II subunit RPB11-b2 (POLR2J3) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family Q9H1A7
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
Tripartite motif-containing protein 10 (TRIM10) TRIM/RBCC family Q9UDY6
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
E3 ubiquitin-protein ligase FANCL (FANCL) . Q9NW38
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
MyoD family inhibitor (MDFI) MDFI family Q99750
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CREB/ATF bZIP transcription factor (CREBZF) BZIP family Q9NS37
SAM pointed domain-containing Ets transcription factor (SPDEF) ETS family O95238
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Golgin-45 (BLZF1) . Q9H2G9
Homeobox protein notochord (NOTO) . A8MTQ0
Transcriptional adapter 2-alpha (TADA2A) . O75478
Other
Click To Hide/Show 54 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Progranulin (GRN) Granulin family P28799
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Peripherin (PRPH) Intermediate filament family P41219
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 12-like protein (MED12L) Mediator complex subunit 12 family Q86YW9
LRP chaperone MESD (MESD) MESD family Q14696
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
Testis-expressed protein 13A (TEX13A) TEX13 family Q9BXU3
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Centrobin (CNTROB) . Q8N137
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
IQ domain-containing protein E (IQCE) . Q6IPM2
Kelch-like protein 42 (KLHL42) . Q9P2K6
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
PRKCA-binding protein (PICK1) . Q9NRD5
Protein hinderin (KIAA1328) . Q86T90
Protein inscuteable homolog (INSC) . Q1MX18
Protein KASH5 (KASH5) . Q8N6L0
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
Puratrophin-1 (PLEKHG4) . Q58EX7
Sperm-associated antigen 5 (SPAG5) . Q96R06
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402