Details of the Target

General Information of Target

Target ID LDTP07173
Target Name Centrosomal protein of 162 kDa (CEP162)
Gene Name CEP162
Gene ID 22832
Synonyms
C6orf84; KIAA1009; QN1; Centrosomal protein of 162 kDa; Cep162; Protein QN1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLL
GTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGV
GLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEH
ENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANV
VLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIA
HSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFG
ISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTN
ESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGA
VMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSK
NLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTD
SLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEK
ELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGY
QQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTR
NQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEK
LYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAES
GNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKN
TVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHD
SPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQ
AHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVL
HSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAV
MNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLI
RHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK
QMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVL
RELHRQGVVVPVAFADEMNAPEY
Target Bioclass
Other
Family
CEP162 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function
Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.
Uniprot ID
Q5TB80
Ensemble ID
ENST00000257766.8
HGNC ID
HGNC:21107

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.E217K .
A375 SNV: p.L125Ter .
CAL27 SNV: p.A638V .
DETROIT562 SNV: p.A876T .
HEC1 SNV: p.G304Ter .
HT115 SNV: p.E659G; p.F753L .
HUH7 SNV: p.D255Y .
KNS81FD SNV: p.E231K .
LS180 SNV: p.T599I .
MDAMB453 SNV: p.E790K; p.R937K .
MEWO SNV: p.P214L .
MFE296 SNV: p.E621D .
NCIH358 SNV: p.E1182Ter .
PC14 Deletion: p.E85IfsTer3 .
SKN SNV: p.Q992H .
TE4 SNV: p.R1299K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C427(1.01); C1014(1.11)  LDD1507  [1]
ATP probe
 Probe Info  		K821(0.00); K823(0.00)  LDD0199  [2]
W1
 Probe Info  		S546(0.00); S548(0.00)  LDD0236  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C427(1.01); C1014(1.11)  LDD1507  [1]
 LDCM0237  AC12 HEK-293T C427(1.04)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C427(1.06)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C427(1.10); C1014(1.12)  LDD1515  [1]
 LDCM0280  AC20 HEK-293T C427(0.78)  LDD1519  [1]
 LDCM0283  AC23 HEK-293T C427(1.18)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C427(0.98); C1014(1.06)  LDD1524  [1]
 LDCM0288  AC28 HEK-293T C427(0.74)  LDD1527  [1]
 LDCM0292  AC31 HEK-293T C427(0.75)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C427(0.76); C1014(1.08)  LDD1533  [1]
 LDCM0297  AC36 HEK-293T C427(0.88)  LDD1536  [1]
 LDCM0300  AC39 HEK-293T C427(0.89)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C427(0.83)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C427(0.75); C1014(1.08)  LDD1542  [1]
 LDCM0306  AC44 HEK-293T C427(0.97)  LDD1545  [1]
 LDCM0309  AC47 HEK-293T C427(0.96)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C427(1.37); C1014(1.09)  LDD1550  [1]
 LDCM0315  AC52 HEK-293T C427(0.78)  LDD1554  [1]
 LDCM0318  AC55 HEK-293T C427(1.30)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C427(0.77); C1014(1.03)  LDD1559  [1]
 LDCM0324  AC60 HEK-293T C427(0.86)  LDD1563  [1]
 LDCM0327  AC63 HEK-293T C427(1.17)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C427(0.88)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C427(0.95); C1014(1.03)  LDD1570  [1]
 LDCM0379  CL11 HEK-293T C427(1.03)  LDD1583  [1]
 LDCM0404  CL17 HEK-293T C427(0.82); C1014(1.32)  LDD1608  [1]
 LDCM0408  CL20 HEK-293T C427(1.20)  LDD1612  [1]
 LDCM0411  CL23 HEK-293T C427(0.81)  LDD1615  [1]
 LDCM0417  CL29 HEK-293T C427(1.10); C1014(1.03)  LDD1621  [1]
 LDCM0421  CL32 HEK-293T C427(1.09)  LDD1625  [1]
 LDCM0424  CL35 HEK-293T C427(1.17)  LDD1628  [1]
 LDCM0431  CL41 HEK-293T C427(1.17); C1014(1.10)  LDD1635  [1]
 LDCM0434  CL44 HEK-293T C427(0.82)  LDD1638  [1]
 LDCM0437  CL47 HEK-293T C427(1.20)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C427(1.18); C1014(1.23)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C427(0.94); C1014(0.98)  LDD1647  [1]
 LDCM0447  CL56 HEK-293T C427(0.83)  LDD1650  [1]
 LDCM0450  CL59 HEK-293T C427(1.44)  LDD1653  [1]
 LDCM0457  CL65 HEK-293T C427(1.15); C1014(1.01)  LDD1660  [1]
 LDCM0460  CL68 HEK-293T C427(0.85)  LDD1663  [1]
 LDCM0464  CL71 HEK-293T C427(1.50)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C427(0.83); C1014(1.10)  LDD1673  [1]
 LDCM0473  CL8 HEK-293T C427(0.98)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C427(1.00)  LDD1677  [1]
 LDCM0477  CL83 HEK-293T C427(0.90)  LDD1680  [1]
 LDCM0483  CL89 HEK-293T C427(0.84); C1014(1.16)  LDD1686  [1]
 LDCM0487  CL92 HEK-293T C427(0.97)  LDD1690  [1]
 LDCM0490  CL95 HEK-293T C427(0.94)  LDD1693  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 120 kDa (CEP120) CEP120 family Q8N960
Centrosomal protein of 135 kDa (CEP135) CEP135/TSGA10 family Q66GS9
Centrosomal protein of 290 kDa (CEP290) . O15078

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.