Details of the Target

General Information of Target

Target ID LDTP07062
Target Name Ventral anterior homeobox 1 (VAX1)
Gene Name VAX1
Gene ID 11023
Synonyms
Ventral anterior homeobox 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFGKPDKMDVRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDC
NKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQ
RCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLR
LLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAPGPAGAA
SPHPPAVGGAPGPGPAGPGGLHAGAPAAGHSLFSLPVPSLLGSVASRLSSAPLTMAGSLA
GNLQELSARYLSSSAFEPYSRTNNKEGAEKKALD
Target Bioclass
Transcription factor
Family
EMX homeobox family
Subcellular location
Nucleus
Function
Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk.
Uniprot ID
Q5SQQ9
Ensemble ID
ENST00000277905.6
HGNC ID
HGNC:12660

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KARPAS422 SNV: p.L137R .
NCIH1155 SNV: p.G127V .
RKO SNV: p.R104H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C74(1.53)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C12(1.12)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C12(1.09)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C12(1.27)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C12(1.34)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C12(1.33)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C12(1.14)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C12(1.23)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C12(1.26)  LDD1514  [2]
 LDCM0390  CL12 HEK-293T C12(1.37)  LDD1594  [2]
 LDCM0412  CL24 HEK-293T C12(1.33)  LDD1616  [2]
 LDCM0425  CL36 HEK-293T C12(1.25)  LDD1629  [2]
 LDCM0438  CL48 HEK-293T C12(1.56)  LDD1642  [2]
 LDCM0452  CL60 HEK-293T C12(1.52)  LDD1655  [2]
 LDCM0465  CL72 HEK-293T C12(1.28)  LDD1668  [2]
 LDCM0478  CL84 HEK-293T C12(1.28)  LDD1681  [2]
 LDCM0491  CL96 HEK-293T C12(1.02)  LDD1694  [2]
 LDCM0022  KB02 HCT 116 C74(1.53)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C74(1.35)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C74(1.71)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402