Details of the Target

General Information of Target

Target ID LDTP06991
Target Name NHS-like protein 2 (NHSL2)
Gene Name NHSL2
Gene ID 340527
Synonyms
NHS-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPFYRRTVVPQRLCPRNPPQQLAELRDVSHLAALSLLRQLADLCGHSLALLEDLEGHLLA
LGRRTDSLYRRTVRLRRRLPCRLLGPEEDEEELAAANSGRENATATAHSRSSWRQPVNVF
LSSGRPPSVEELLREAQLNLQSLLQEEYEEQYSEARLVGQTFRSSDEATKPTPNPRPQSA
RRLEFILMPTKRQLSEDETTTQGVRAPEASLSLSTTADKQTAWNSLFPLPILEEKRWPQL
CSTQSDIVPINISGQQFDKHASLRHSLFNTETAVNPKSTLRRRRTIIGFSNFSQRDQGHS
NSPAGSVAHSTTSDIRPSHSVPEGVHGRVAVGQDARFPSLTSPVLRTPSSEPDEPHQARS
GPNPPGMESMGMVYSVPSSCNGPTESTFSTSWKGDAFTYMTPSATSQSNQVNENGKNPSC
GNSWVSLNKVPPLVPKEAATLLVARDNPAGCSGSAGYPERLIQQRHMPERPSKIGLLTSG
TSRLETGPGGASRFRERSLSVPTDSGTTDVDYDEEQKANEACALPFASTSSEGSNSADNI
ASLSAQQEAQHRRQRSKSISLRKAKKKPSPPTRSVSLVKDEPGLLPEGGSALPKDQRPKS
LCLSLEHQGHHSSHPDAQGHPAIPNHKDPESTQFSHHWYLTDWKSGDTYQSLSSSSTATG
TTVIECTQVQGSSESLASPSTSRATTPSQLSIEVEAREISSPGRPPGLMSPSSGYSSQSE
TPTPTVSMSLTLGHLPPPSSSVRVRPVVPERKSSLPPTSPMEKFPKSRLSFDLPLTSSPN
LDLSGMSISIRSKTKVSRHHSETNFGVKLAQKTNPNQPIMPMVTQSDLRSVRLRSVSKSE
PEDDIESPEYAEEPRAEEVFTLPERKTKPPVAEKPPVARRPPSLVHKPPSVPEEYALTSP
TLAMPPRSSIQHARPLPQDSYTVVRKPKPSSFPDGRSPGESTAPSSLVFTPFASSSDAFF
SGTQQPPQGSVEDEGPKVRVLPERISLQSQEEAEKKKGKIPPPVPKKPSVLYLPLTSPTA
QMEAYVAEPRLPLSPIITLEEDTKCPATGDDLQSLGQRVTSTPQADSEREASPLGSSVEP
GTEEKSLISDKTAEWIAEDDDDVFVASRTTEDLFTVIHRSKRKLLGWKEPGEAFVGGRTS
SHSPIKNTAESPISESTATAGSGSSANLDAGRNDDFKALLQKKGSKATPRSRPSAAELLK
TTNPLARRIIAQFSKDYETTDNPST
Target Bioclass
Other
Family
NHS family
Uniprot ID
Q5HYW2
Ensemble ID
ENST00000510661.2
HGNC ID
HGNC:33737

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C679(1.74)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C1045(1.10)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C1045(1.00)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C1045(1.02)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C1045(1.23)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C1045(1.21)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C1045(1.20)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C1045(1.61)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C1045(1.00)  LDD1514  [2]
 LDCM0390  CL12 HEK-293T C1045(1.01)  LDD1594  [2]
 LDCM0412  CL24 HEK-293T C1045(1.13)  LDD1616  [2]
 LDCM0425  CL36 HEK-293T C1045(0.96)  LDD1629  [2]
 LDCM0438  CL48 HEK-293T C1045(0.95)  LDD1642  [2]
 LDCM0452  CL60 HEK-293T C1045(1.52)  LDD1655  [2]
 LDCM0465  CL72 HEK-293T C1045(1.17)  LDD1668  [2]
 LDCM0478  CL84 HEK-293T C1045(1.30)  LDD1681  [2]
 LDCM0491  CL96 HEK-293T C1045(1.04)  LDD1694  [2]
 LDCM0022  KB02 A2780 C679(1.54)  LDD2254  [1]
 LDCM0023  KB03 A2780 C679(1.36)  LDD2671  [1]
 LDCM0024  KB05 NB1 C679(1.74)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402