Details of the Target

General Information of Target

Target ID LDTP06447
Target Name ALX homeobox protein 1 (ALX1)
Gene Name ALX1
Gene ID 8092
Synonyms
CART1; ALX homeobox protein 1; Cartilage homeoprotein 1; CART-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFLSEKFALKSPPSKNSDFYMGAGGPLEHVMETLDNESFYSKASAGKCVQAFGPLPRAE
HHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRMSPVKGMQEKGELDELG
DKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWF
QNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCM
LPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPE
FERRSSSIAVLRMKAKEHTANISWAM
Target Bioclass
Transcription factor
Family
Paired homeobox family
Subcellular location
Nucleus
Function
Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1.
Uniprot ID
Q15699
Ensemble ID
ENST00000316824.4
HGNC ID
HGNC:1494

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C123(1.44)  LDD0080  [1]
IPM
 Probe Info  		C71(0.00); C99(0.00)  LDD2156  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C123(1.05)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C123(1.12)  LDD1509  [4]
 LDCM0270  AC15 HEK-293T C123(1.04); C49(0.98)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C123(0.81)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C123(1.57)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C123(0.76)  LDD1518  [4]
 LDCM0283  AC23 HEK-293T C123(1.00); C49(1.12)  LDD1522  [4]
 LDCM0286  AC26 HEK-293T C123(0.91)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C123(1.19)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C123(0.90)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C123(0.87); C49(0.97)  LDD1531  [4]
 LDCM0295  AC34 HEK-293T C123(0.72)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C123(0.96)  LDD1535  [4]
 LDCM0300  AC39 HEK-293T C123(1.40); C49(1.10)  LDD1539  [4]
 LDCM0304  AC42 HEK-293T C123(0.89)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C123(1.27)  LDD1544  [4]
 LDCM0309  AC47 HEK-293T C123(1.17); C49(1.06)  LDD1548  [4]
 LDCM0313  AC50 HEK-293T C123(1.05)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C123(0.97)  LDD1553  [4]
 LDCM0318  AC55 HEK-293T C123(1.35); C49(1.03)  LDD1557  [4]
 LDCM0321  AC58 HEK-293T C123(1.08)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C123(0.83)  LDD1561  [4]
 LDCM0327  AC63 HEK-293T C123(0.95); C49(1.13)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C123(1.19); C49(1.26)  LDD1568  [4]
 LDCM0369  CL100 HEK-293T C123(1.03)  LDD1573  [4]
 LDCM0372  CL103 HEK-293T C123(1.59)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C123(1.17)  LDD1577  [4]
 LDCM0376  CL107 HEK-293T C123(1.77)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C123(1.56)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C123(1.21); C49(1.09)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C123(1.19)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C123(1.47)  LDD1586  [4]
 LDCM0385  CL115 HEK-293T C123(1.22)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C123(1.35)  LDD1590  [4]
 LDCM0389  CL119 HEK-293T C123(1.58)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C123(1.06)  LDD1595  [4]
 LDCM0394  CL123 HEK-293T C123(1.19)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C123(1.18)  LDD1599  [4]
 LDCM0398  CL127 HEK-293T C123(1.66)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C123(1.15)  LDD1603  [4]
 LDCM0402  CL15 HEK-293T C123(1.24)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C123(1.16)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C123(1.07)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C123(0.91)  LDD1610  [4]
 LDCM0411  CL23 HEK-293T C123(1.24); C49(1.11)  LDD1615  [4]
 LDCM0415  CL27 HEK-293T C123(1.05)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C123(1.28)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C123(1.02)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C123(0.88)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C123(1.22)  LDD1624  [4]
 LDCM0424  CL35 HEK-293T C123(1.43); C49(0.98)  LDD1628  [4]
 LDCM0428  CL39 HEK-293T C123(0.97)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C123(0.86)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C123(1.17)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C123(1.39)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C123(1.00)  LDD1637  [4]
 LDCM0437  CL47 HEK-293T C123(1.32); C49(1.11)  LDD1641  [4]
 LDCM0443  CL52 HEK-293T C123(1.18)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C123(0.93)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C123(1.08)  LDD1649  [4]
 LDCM0450  CL59 HEK-293T C123(1.23); C49(0.94)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C123(0.78)  LDD1654  [4]
 LDCM0455  CL63 HEK-293T C123(1.61)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C123(1.09)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C123(0.94)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C123(0.98)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C123(1.07)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C123(1.00); C49(0.93)  LDD1667  [4]
 LDCM0469  CL76 HEK-293T C123(1.32)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C123(0.89)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C123(1.14)  LDD1675  [4]
 LDCM0477  CL83 HEK-293T C123(1.34); C49(0.97)  LDD1680  [4]
 LDCM0481  CL87 HEK-293T C123(1.06)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C123(0.99)  LDD1685  [4]
 LDCM0485  CL90 HEK-293T C123(0.91)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C123(1.08)  LDD1689  [4]
 LDCM0490  CL95 HEK-293T C123(1.21); C49(1.02)  LDD1693  [4]
 LDCM0494  CL99 HEK-293T C123(1.11)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C123(1.37)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C123(1.10)  LDD1671  [4]
 LDCM0022  KB02 HCT 116 C123(1.44)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C123(1.35)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C123(1.96)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Urocanate hydratase (UROC1) Urocanase family Q96N76
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Importin-13 (IPO13) Importin beta family O94829
Serum amyloid P-component (APCS) Pentraxin family P02743
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Olfactory receptor 52L1 (OR52L1) G-protein coupled receptor 1 family Q8NGH7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gastrin-releasing peptide (GRP) Bombesin/neuromedin-B/ranatensin family P07492
Keratin-associated protein 4-4 (KRTAP4-4) KRTAP type 4 family Q9BYR3

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402