Details of the Target

General Information of Target

Target ID LDTP06318
Target Name Procollagen C-endopeptidase enhancer 1 (PCOLCE)
Gene Name PCOLCE
Gene ID 5118
Synonyms
PCPE1; Procollagen C-endopeptidase enhancer 1; Procollagen COOH-terminal proteinase enhancer 1; PCPE-1; Procollagen C-proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPN
KECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPL
VAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDY
PPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAV
PGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKS
QPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSL
IGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVL
HRPNQDQILTNLSKRKCPSQPVRAAASQD
Target Bioclass
Enzyme
Subcellular location
Secreted
Function Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
Uniprot ID
Q15113
Ensemble ID
ENST00000223061.6
HGNC ID
HGNC:8738

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		92.98  LDD0318  [1]
DBIA
 Probe Info  		C159(1.94)  LDD3311  [2]
BTD
 Probe Info  		C159(0.88)  LDD2097  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C159(3.17)  LDD2244  [2]
 LDCM0023  KB03 42-MG-BA C159(2.32)  LDD2661  [2]
 LDCM0024  KB05 G361 C159(1.94)  LDD3311  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C159(0.88)  LDD2097  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C159(0.63)  LDD2115  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C159(0.56)  LDD2134  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C159(0.43)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bone morphogenetic protein 1 (BMP1) . P13497
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Collagen alpha-1(V) chain (COL5A1) Fibrillar collagen family P20908
Thrombospondin-1 (THBS1) Thrombospondin family P07996

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761