Details of the Target

General Information of Target

Target ID LDTP06317
Target Name Inactive phospholipase C-like protein 1 (PLCL1)
Gene Name PLCL1
Gene ID 5334
Synonyms
Inactive phospholipase C-like protein 1; PLC-L1; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; PRIP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRDRRSGVALPGAAGTPAD
SEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSANDCISFMQAGCE
LKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGL
ADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPR
FMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTE
EEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRY
ELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIED
QFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAF
VASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVK
GKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDF
ELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFW
NCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSP
LALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDE
TFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVT
LFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDM
RENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAI
PDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKL
NKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSL
EAIEEKESSEENGKL
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Uniprot ID
Q15111
Ensemble ID
ENST00000428675.6
HGNC ID
HGNC:9063

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G118V .
786O SNV: p.Y953F .
A2058 SNV: p.G690R .
A431 SNV: p.H892Y .
BICR22 SNV: p.P748S .
HCC15 SNV: p.L828M .
HEC1 SNV: p.F468L .
HEC1B SNV: p.F468L .
HT115 SNV: p.R469Ter; p.S606I .
KYSE510 SNV: p.E913K .
LOXIMVI SNV: p.A741T .
LU65 SNV: p.T517S .
NCIH1703 Deletion: p.L841FfsTer5 .
NCIH1944 SNV: p.V471F .
NCIH2172 SNV: p.P239T; p.S944Ter .
NCIH358 SNV: p.G370R .
NCIH446 SNV: p.R129L .
OVK18 SNV: p.E233D .
REH SNV: p.R622H .
RL952 SNV: p.E817K .
SNGM SNV: p.T517I .
SNU308 Deletion: p.W610GfsTer38 .
SW1271 SNV: p.G7V .
TOV21G SNV: p.I835T .
UACC62 Deletion: p.D399PfsTer17 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C33(1.94)  LDD3397  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C33(1.05)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C33(1.11)  LDD1523  [3]
 LDCM0289  AC29 HEK-293T C33(1.15)  LDD1528  [3]
 LDCM0293  AC32 HEK-293T C33(0.96)  LDD1532  [3]
 LDCM0298  AC37 HEK-293T C33(1.23)  LDD1537  [3]
 LDCM0302  AC40 HEK-293T C33(1.07)  LDD1541  [3]
 LDCM0307  AC45 HEK-293T C33(1.08)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C33(1.09)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C33(1.05)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C33(1.10)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C33(1.11)  LDD1558  [3]
 LDCM0325  AC61 HEK-293T C33(1.09)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C33(0.99)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C33(1.23)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C33(0.95)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C33(0.98)  LDD1514  [3]
 LDCM0390  CL12 HEK-293T C33(1.11)  LDD1594  [3]
 LDCM0409  CL21 HEK-293T C33(1.08)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C33(1.08)  LDD1616  [3]
 LDCM0422  CL33 HEK-293T C33(1.14)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C33(1.20)  LDD1629  [3]
 LDCM0435  CL45 HEK-293T C33(0.97)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C33(1.42)  LDD1642  [3]
 LDCM0448  CL57 HEK-293T C33(1.01)  LDD1651  [3]
 LDCM0452  CL60 HEK-293T C33(1.17)  LDD1655  [3]
 LDCM0461  CL69 HEK-293T C33(1.14)  LDD1664  [3]
 LDCM0465  CL72 HEK-293T C33(1.00)  LDD1668  [3]
 LDCM0475  CL81 HEK-293T C33(0.99)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C33(1.19)  LDD1681  [3]
 LDCM0484  CL9 HEK-293T C33(1.26)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C33(1.19)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C33(0.94)  LDD1694  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 DEL C33(1.71)  LDD2315  [1]
 LDCM0023  KB03 DEL C33(1.90)  LDD2732  [1]
 LDCM0024  KB05 PF-382 C33(1.94)  LDD3397  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Quinacrine Small molecular drug DB01103

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402