Details of the Target

General Information of Target

Target ID LDTP06113
Target Name Growth arrest-specific protein 6 (GAS6)
Gene Name GAS6
Gene ID 2621
Synonyms
AXLLG; Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGH
LERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQC
TPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHC
SCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVD
ECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRM
FSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLR
YNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLN
LTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFY
PGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALV
DYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVS
AAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAY
KHSDITAHSCPPVEPAAA
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Secreted
Function
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.; (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.
TTD ID
T42974
Uniprot ID
Q14393
DrugMap ID
TT69QD2
Ensemble ID
ENST00000327773.7
HGNC ID
HGNC:4168
ChEMBL ID
CHEMBL4804247

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K293(1.08)  LDD0277  [1]
DBIA
 Probe Info  		C513(2.27)  LDD3380  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C470(0.91)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C470(0.83)  LDD1509  [4]
 LDCM0270  AC15 HEK-293T C133(0.93)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C470(0.80)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C470(1.09)  LDD1517  [4]
 LDCM0283  AC23 HEK-293T C133(0.89)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C470(1.01)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C470(1.14)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C470(1.08)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C133(0.99)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C470(0.94)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C470(0.97)  LDD1535  [4]
 LDCM0300  AC39 HEK-293T C133(0.91)  LDD1539  [4]
 LDCM0303  AC41 HEK-293T C470(0.87)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C470(0.90)  LDD1544  [4]
 LDCM0309  AC47 HEK-293T C133(0.95)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C470(1.01)  LDD1550  [4]
 LDCM0314  AC51 HEK-293T C470(0.89)  LDD1553  [4]
 LDCM0318  AC55 HEK-293T C133(0.79)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C470(1.12)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C470(0.89)  LDD1561  [4]
 LDCM0327  AC63 HEK-293T C133(1.08)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C133(1.03)  LDD1568  [4]
 LDCM0356  AKOS034007680 HEK-293T C470(0.78)  LDD1570  [4]
 LDCM0369  CL100 HEK-293T C470(1.16)  LDD1573  [4]
 LDCM0372  CL103 HEK-293T C470(0.80)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C470(1.22)  LDD1577  [4]
 LDCM0376  CL107 HEK-293T C470(1.08)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C470(1.10)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C133(1.71)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C470(1.20)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C470(0.89)  LDD1586  [4]
 LDCM0385  CL115 HEK-293T C470(1.04)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C470(1.13)  LDD1590  [4]
 LDCM0389  CL119 HEK-293T C470(0.96)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C470(0.91)  LDD1595  [4]
 LDCM0394  CL123 HEK-293T C470(1.23)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C470(1.22)  LDD1599  [4]
 LDCM0398  CL127 HEK-293T C470(1.18)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C470(1.19)  LDD1603  [4]
 LDCM0402  CL15 HEK-293T C470(0.92)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C470(1.06)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C470(1.08)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C470(1.01)  LDD1610  [4]
 LDCM0411  CL23 HEK-293T C133(1.34)  LDD1615  [4]
 LDCM0415  CL27 HEK-293T C470(0.92)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C470(0.79)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C470(0.85)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C470(1.06)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C470(0.66)  LDD1624  [4]
 LDCM0424  CL35 HEK-293T C133(1.34)  LDD1628  [4]
 LDCM0428  CL39 HEK-293T C470(1.14)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C470(0.93)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C470(0.96)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C470(1.00)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C470(0.90)  LDD1637  [4]
 LDCM0437  CL47 HEK-293T C133(1.67)  LDD1641  [4]
 LDCM0440  CL5 HEK-293T C470(0.90)  LDD1644  [4]
 LDCM0443  CL52 HEK-293T C470(0.99)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C470(1.33)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C470(0.85)  LDD1649  [4]
 LDCM0450  CL59 HEK-293T C133(1.41)  LDD1653  [4]
 LDCM0455  CL63 HEK-293T C470(1.39)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C470(1.03)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C470(1.02)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C470(0.94)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C470(0.91)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C133(1.33)  LDD1667  [4]
 LDCM0469  CL76 HEK-293T C470(0.92)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C470(0.93)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C470(1.07)  LDD1675  [4]
 LDCM0477  CL83 HEK-293T C133(1.20)  LDD1680  [4]
 LDCM0481  CL87 HEK-293T C470(1.17)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C470(0.99)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C470(0.94)  LDD1686  [4]
 LDCM0486  CL91 HEK-293T C470(0.89)  LDD1689  [4]
 LDCM0490  CL95 HEK-293T C133(1.27)  LDD1693  [4]
 LDCM0494  CL99 HEK-293T C470(1.11)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C470(1.18)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C470(1.00)  LDD1671  [4]
 LDCM0022  KB02 BT-549 C513(2.03); C613(1.66)  LDD2279  [2]
 LDCM0023  KB03 BT-549 C513(1.77)  LDD2696  [2]
 LDCM0024  KB05 OV-90 C513(2.27)  LDD3380  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402