Details of the Target

General Information of Target

Target ID LDTP06074
Target Name Transcription factor Dp-2 (TFDP2)
Gene Name TFDP2
Gene ID 7029
Synonyms
DP2; Transcription factor Dp-2; E2F dimerization partner 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAKNVGLTSTNAEVRGFIDQNLSPTKGNISFVAFPVSNTNSPTKILPKTLGPINVNVGP
QMIISTPQRLTSSGSVLIGSPYTPAPAMVTQTHIAEATGWVPGDRKRARKFIDSDFSESK
RSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNSNNHLAADSAYDQKNI
RRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERIKQKRAQLQE
LLLQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLF
NFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLN
QGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPNSHQSSSAASHCS
ESRGETPCSFNDEDEEDDEEDSSSPE
Target Bioclass
Transcription factor
Family
E2F/DP family
Subcellular location
Nucleus
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Uniprot ID
Q14188
Ensemble ID
ENST00000467072.5
HGNC ID
HGNC:11751
ChEMBL ID
CHEMBL4105986

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB2 SNV: p.S213C .
HT1080 SNV: p.V159L .
LOXIMVI SNV: p.R145Q .
MFE319 Insertion: p.E203RfsTer57 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C81(2.01)  LDD3403  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C217(0.97)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C217(0.99)  LDD1513  [4]
 LDCM0281  AC21 HEK-293T C217(1.01)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C217(0.84)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C217(0.97)  LDD1522  [4]
 LDCM0289  AC29 HEK-293T C217(1.20)  LDD1528  [4]
 LDCM0291  AC30 HEK-293T C217(0.88)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C217(1.29)  LDD1531  [4]
 LDCM0298  AC37 HEK-293T C217(1.10)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C217(0.69)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C217(0.83)  LDD1539  [4]
 LDCM0307  AC45 HEK-293T C217(1.03)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C217(1.14)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C217(1.09)  LDD1548  [4]
 LDCM0312  AC5 HEK-293T C217(1.07)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C217(0.92)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C217(0.93)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C217(1.13)  LDD1557  [4]
 LDCM0323  AC6 HEK-293T C217(0.83)  LDD1562  [4]
 LDCM0325  AC61 HEK-293T C217(1.06)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C217(0.95)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C217(1.06)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C217(1.21)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C217(1.23)  LDD1511  [4]
 LDCM0367  CL1 HEK-293T C217(1.11)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C217(0.80)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C217(1.03)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C217(1.11)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C217(1.04)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C217(0.91)  LDD1583  [4]
 LDCM0383  CL113 HEK-293T C217(1.08)  LDD1587  [4]
 LDCM0387  CL117 HEK-293T C217(1.19)  LDD1591  [4]
 LDCM0392  CL121 HEK-293T C217(1.04)  LDD1596  [4]
 LDCM0396  CL125 HEK-293T C217(1.21)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C217(1.36)  LDD1604  [4]
 LDCM0409  CL21 HEK-293T C217(0.92)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C217(0.95)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C217(1.09)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C217(1.26)  LDD1617  [4]
 LDCM0422  CL33 HEK-293T C217(1.19)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C217(1.51)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C217(0.94)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C217(1.23)  LDD1630  [4]
 LDCM0435  CL45 HEK-293T C217(1.16)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C217(0.72)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C217(1.14)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C217(1.16)  LDD1643  [4]
 LDCM0448  CL57 HEK-293T C217(0.99)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C217(0.81)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C217(1.28)  LDD1653  [4]
 LDCM0453  CL61 HEK-293T C217(1.13)  LDD1656  [4]
 LDCM0461  CL69 HEK-293T C217(1.38)  LDD1664  [4]
 LDCM0463  CL70 HEK-293T C217(1.27)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C217(1.07)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C217(1.00)  LDD1669  [4]
 LDCM0475  CL81 HEK-293T C217(0.93)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C217(0.81)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C217(0.74)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C217(1.31)  LDD1682  [4]
 LDCM0484  CL9 HEK-293T C217(0.97)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C217(1.19)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C217(1.22)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C217(1.28)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C217(1.10)  LDD1695  [4]
 LDCM0022  KB02 697 C81(1.60)  LDD2245  [1]
 LDCM0023  KB03 697 C81(1.99)  LDD2662  [1]
 LDCM0024  KB05 Reh C81(2.01)  LDD3403  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor E2F4 (E2F4) E2F/DP family Q16254
Transcription factor E2F6 (E2F6) E2F/DP family O75461

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402