Details of the Target

General Information of Target

Target ID LDTP06013
Target Name Nuclear transcription factor Y subunit gamma (NFYC)
Gene Name NFYC
Gene ID 4802
Synonyms
Nuclear transcription factor Y subunit gamma; CAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; NF-YC; Transactivator HSM-1/2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKM
ISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPR
DELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII
AQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIP
VQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQGQRNASQGKPRRCLKETLQITQTE
VQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKATGNSTPCTSSLPTTHPPSHRAG
ASCVCCSQPQQSSTSPPPSDALQWVVVEVSGTPNQLETHRELHAPLPGMTSLSPLHPSQQ
LYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD
Target Bioclass
Transcription factor
Family
NFYC/HAP5 subunit family
Subcellular location
Nucleus
Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Uniprot ID
Q13952
Ensemble ID
ENST00000308733.9
HGNC ID
HGNC:7806

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K71(1.42)  LDD2217  [1]
IA-alkyne
 Probe Info  		C345(0.94)  LDD2191  [2]
DBIA
 Probe Info  		C345(1.15)  LDD1492  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C345(1.43)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C345(1.01)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C345(0.94)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C345(1.15)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C345(1.06)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C345(1.43)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C345(1.33)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C345(0.95)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C345(0.87)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C345(0.89)  LDD1522  [3]
 LDCM0286  AC26 HEK-293T C345(1.34)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C345(0.86)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C345(1.10)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C345(0.93)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C345(1.07)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C345(0.94)  LDD1531  [3]
 LDCM0295  AC34 HEK-293T C345(1.43)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C345(0.87)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C345(0.95)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C345(0.85)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C345(0.94)  LDD1539  [3]
 LDCM0304  AC42 HEK-293T C345(1.47)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C345(1.01)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C345(1.23)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C345(0.69)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C345(1.95)  LDD1548  [3]
 LDCM0312  AC5 HEK-293T C345(1.08)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C345(1.07)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C345(0.89)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C345(1.07)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C345(1.01)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C345(1.43)  LDD1557  [3]
 LDCM0321  AC58 HEK-293T C345(1.45)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C345(1.06)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C345(1.08)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C345(0.94)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C345(0.86)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C345(0.90)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C345(1.18)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C345(1.14)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C345(1.04)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C345(1.32)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C345(0.95)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C345(0.83)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C345(1.30)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C345(0.88)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C345(1.29)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C345(0.67)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C345(1.09)  LDD1585  [3]
 LDCM0383  CL113 HEK-293T C345(1.37)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C345(0.98)  LDD1589  [3]
 LDCM0387  CL117 HEK-293T C345(1.25)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C345(0.85)  LDD1593  [3]
 LDCM0392  CL121 HEK-293T C345(1.11)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C345(0.69)  LDD1598  [3]
 LDCM0396  CL125 HEK-293T C345(0.90)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C345(0.70)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C345(1.39)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C345(0.86)  LDD1606  [3]
 LDCM0405  CL18 HEK-293T C345(0.94)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C345(0.96)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C345(0.99)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C345(1.11)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C345(1.17)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C345(0.85)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C345(0.80)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C345(0.74)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C345(1.28)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C345(0.90)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C345(0.78)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C345(0.76)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C345(0.74)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C345(1.00)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C345(0.80)  LDD1632  [3]
 LDCM0432  CL42 HEK-293T C345(1.03)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C345(0.86)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C345(0.78)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C345(0.82)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C345(1.14)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C345(1.10)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C345(1.25)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C345(0.95)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C345(1.26)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C345(1.01)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C345(0.89)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C345(1.20)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C345(1.13)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C345(1.00)  LDD1658  [3]
 LDCM0458  CL66 HEK-293T C345(1.12)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C345(0.84)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C345(0.81)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C345(0.90)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C345(0.92)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C345(0.82)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C345(1.12)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C345(1.11)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C345(1.03)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C345(0.77)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C345(0.83)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C345(1.01)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C345(0.96)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C345(0.66)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C345(1.04)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C345(0.85)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C345(0.84)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C345(0.74)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C345(0.90)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C345(0.65)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C345(1.03)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C345(0.85)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C345(0.91)  LDD1698  [3]
 LDCM0574  Fragment12 Ramos C345(0.94)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C345(0.71)  LDD2192  [2]
 LDCM0579  Fragment20 Ramos C345(0.69)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C345(0.71)  LDD2195  [2]
 LDCM0586  Fragment28 Ramos C345(0.84)  LDD2198  [2]
 LDCM0590  Fragment32 Ramos C345(1.62)  LDD2201  [2]
 LDCM0468  Fragment33 HEK-293T C345(0.96)  LDD1671  [3]
 LDCM0022  KB02 HEK-293T C345(1.15)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C345(0.97)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C345(1.11)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dehydrogenase/reductase SDR family member 6 (BDH2) Short-chain dehydrogenases/reductases (SDR) family Q9BUT1
SUMO-activating enzyme subunit 1 (SAE1) Ubiquitin-activating E1 family Q9UBE0
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Uncharacterized protein CXorf38 (CXorf38) . Q8TB03
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ETS-related transcription factor Elf-1 (ELF1) ETS family P32519
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
Nuclear transcription factor Y subunit alpha (NFYA) NFYA/HAP2 subunit family P23511
Nuclear transcription factor Y subunit beta (NFYB) NFYB/HAP3 subunit family P25208
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
POU domain, class 6, transcription factor 1 (POU6F1) POU transcription factor family Q14863
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
Sterol regulatory element-binding protein 2 (SREBF2) SREBP family Q12772
Circadian-associated transcriptional repressor (CIART) . Q8N365
Paired box protein Pax-5 (PAX5) . Q02548
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adhesion G protein-coupled receptor F5 (ADGRF5) G-protein coupled receptor 2 family Q8IZF2
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Protein lin-54 homolog (LIN54) Lin-54 family Q6MZP7
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Proline-rich protein 20D (PRR20D) PRR20 family P86480
DNA repair protein RAD52 homolog (RAD52) RAD52 family P43351
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
LIM domain transcription factor LMO4 (LMO4) . P61968
Storkhead-box protein 1 (STOX1) . Q6ZVD7
UBX domain-containing protein 7 (UBXN7) . O94888

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255