Details of the Target

General Information of Target

Target ID LDTP05894
Target Name Neuronal membrane glycoprotein M6-b (GPM6B)
Gene Name GPM6B
Gene ID 2824
Synonyms
M6B; Neuronal membrane glycoprotein M6-b; M6b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALA
GTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELH
GEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTT
GVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALL
IYMMATTYNYAVLKFKSREDCCTKF
Target Bioclass
Other
Family
Myelin proteolipid protein family
Subcellular location
Cell membrane
Function
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Uniprot ID
Q13491
Ensemble ID
ENST00000316715.9
HGNC ID
HGNC:4461

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C261(1.13)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C261(1.13)  LDD1507  [1]
 LDCM0226  AC11 HEK-293T C261(1.11)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C261(0.95)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C261(1.06)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C261(1.09)  LDD1515  [1]
 LDCM0278  AC19 HEK-293T C261(0.75)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C261(0.96)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C261(1.00)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C261(1.20)  LDD1524  [1]
 LDCM0287  AC27 HEK-293T C261(1.15)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C261(1.06)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C261(0.91)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C261(1.07)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C261(1.28)  LDD1533  [1]
 LDCM0296  AC35 HEK-293T C261(0.93)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C261(0.96)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C261(1.08)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C261(1.28)  LDD1542  [1]
 LDCM0305  AC43 HEK-293T C261(0.96)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C261(0.98)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C261(0.98)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C261(1.18)  LDD1550  [1]
 LDCM0314  AC51 HEK-293T C261(0.92)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C261(0.85)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C261(1.03)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C261(1.35)  LDD1559  [1]
 LDCM0322  AC59 HEK-293T C261(0.98)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C261(1.00)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C261(1.11)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C261(1.16)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C261(1.09)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C261(1.28)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C261(1.19)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C261(1.83)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C261(1.13)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C262(1.21)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C261(1.00)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C261(1.10)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C262(0.93)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C261(0.91)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C261(1.09)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C261(1.32)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C262(1.05)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C261(1.12)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C261(1.09)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C262(1.19)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C261(0.96)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C261(1.19)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C262(0.92)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C261(1.07)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C261(0.98)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C262(0.93)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C261(1.21)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C261(1.35)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C262(1.13)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C261(1.34)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C261(0.95)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C262(1.03)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C261(1.29)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C261(1.32)  LDD1608  [1]
 LDCM0406  CL19 HEK-293T C261(0.93)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C262(0.85)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C261(1.24)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C261(1.31)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C261(1.48)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C262(0.96)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C261(1.12)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C261(0.93)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C261(0.99)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C261(1.26)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C261(1.12)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C261(1.45)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C261(1.33)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C261(0.99)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C261(1.11)  LDD1635  [1]
 LDCM0433  CL43 HEK-293T C261(0.99)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C261(1.24)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C261(1.45)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C261(1.29)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C261(1.23)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C262(0.91)  LDD1645  [1]
 LDCM0444  CL53 HEK-293T C261(1.28)  LDD1647  [1]
 LDCM0446  CL55 HEK-293T C261(1.14)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C261(1.20)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C261(1.46)  LDD1653  [1]
 LDCM0453  CL61 HEK-293T C261(1.25)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C262(0.79)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C261(1.16)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C261(1.11)  LDD1660  [1]
 LDCM0459  CL67 HEK-293T C261(1.06)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C261(1.02)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C261(1.18)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C261(1.26)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C261(1.50)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C262(0.84)  LDD1670  [1]
 LDCM0470  CL77 HEK-293T C261(1.12)  LDD1673  [1]
 LDCM0472  CL79 HEK-293T C261(1.04)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C261(1.02)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C261(1.25)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C261(2.68)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C262(1.21)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C261(1.34)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C261(1.34)  LDD1686  [1]
 LDCM0486  CL91 HEK-293T C261(1.10)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C261(1.19)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C261(1.73)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C261(1.23)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C262(1.08)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C261(1.17)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C261(1.10)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C261(1.02)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C262(0.86)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-1A (STX1A) Syntaxin family Q16623
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402