Details of the Target

General Information of Target

Target ID LDTP05603
Target Name Sodium/bile acid cotransporter 7 (SLC10A7)
Gene Name SLC10A7
Gene ID 84068
Synonyms
C4orf13; P7; Sodium/bile acid cotransporter 7; Na(+)/bile acid cotransporter 7; Solute carrier family 10 member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKT
EELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSS
AVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSSVPFTSIFSQLFMTVVVP
LIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLILFI
IFSIQLSFMLLTFIFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLI
SVPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV
Target Bioclass
Transporter and channel
Family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
Subcellular location
Cell membrane
Function
Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
Uniprot ID
Q0GE19
Ensemble ID
ENST00000335472.12
HGNC ID
HGNC:23088

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C113(1.03)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C113(1.03)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C113(1.05)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C113(1.04)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C113(0.99)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C113(0.91)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C113(1.07)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C113(0.97)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C113(1.03)  LDD1519  [1]
 LDCM0283  AC23 HEK-293T C113(1.00)  LDD1522  [1]
 LDCM0286  AC26 HEK-293T C113(1.11)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C113(1.03)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C113(0.96)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C113(1.06)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C113(1.00)  LDD1531  [1]
 LDCM0295  AC34 HEK-293T C113(1.06)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C113(0.99)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C113(1.14)  LDD1536  [1]
 LDCM0300  AC39 HEK-293T C113(0.96)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C113(1.06)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C113(0.97)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C113(1.05)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C113(1.06)  LDD1545  [1]
 LDCM0309  AC47 HEK-293T C113(1.02)  LDD1548  [1]
 LDCM0313  AC50 HEK-293T C113(0.97)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C113(0.98)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C113(1.05)  LDD1554  [1]
 LDCM0318  AC55 HEK-293T C113(1.03)  LDD1557  [1]
 LDCM0321  AC58 HEK-293T C113(1.10)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C113(1.18)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C113(1.18)  LDD1563  [1]
 LDCM0327  AC63 HEK-293T C113(1.03)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C113(1.10)  LDD1568  [1]
 LDCM0367  CL1 HEK-293T C113(0.96)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C113(0.93)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C113(0.90)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C113(1.04)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C113(1.08)  LDD1583  [1]
 LDCM0383  CL113 HEK-293T C113(0.92)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C113(0.95)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C113(0.99)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C113(1.08)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C113(0.98)  LDD1604  [1]
 LDCM0405  CL18 HEK-293T C113(0.96)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C113(1.00)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C113(1.03)  LDD1612  [1]
 LDCM0411  CL23 HEK-293T C113(1.07)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C113(1.08)  LDD1617  [1]
 LDCM0419  CL30 HEK-293T C113(0.90)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C113(0.98)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C113(0.99)  LDD1625  [1]
 LDCM0424  CL35 HEK-293T C113(1.05)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C113(1.11)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C113(0.99)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C113(1.08)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C113(0.90)  LDD1638  [1]
 LDCM0437  CL47 HEK-293T C113(1.02)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C113(1.05)  LDD1643  [1]
 LDCM0445  CL54 HEK-293T C113(1.15)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C113(1.01)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C113(1.07)  LDD1650  [1]
 LDCM0450  CL59 HEK-293T C113(1.04)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C113(1.16)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C113(1.07)  LDD1656  [1]
 LDCM0458  CL66 HEK-293T C113(1.05)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C113(1.07)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C113(1.08)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C113(1.21)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C113(1.01)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C113(1.05)  LDD1669  [1]
 LDCM0471  CL78 HEK-293T C113(1.09)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C113(0.92)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C113(2.14)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C113(1.05)  LDD1677  [1]
 LDCM0477  CL83 HEK-293T C113(1.06)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C113(1.16)  LDD1682  [1]
 LDCM0485  CL90 HEK-293T C113(1.17)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C113(1.08)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C113(1.23)  LDD1690  [1]
 LDCM0490  CL95 HEK-293T C113(1.30)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C113(1.05)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402