Details of the Target

General Information of Target

Target ID LDTP05445
Target Name Islet cell autoantigen 1 (ICA1)
Gene Name ICA1
Gene ID 3382
Synonyms
Islet cell autoantigen 1; 69 kDa islet cell autoantigen; ICA69; Islet cell autoantigen p69; ICAp69; p69
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKL
ELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKAL
CFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQCRTEYRGALLWMKDVSQEL
DPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLH
FWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEEKKKINQQESTDAAVQEPS
QLISLEEENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVA
GTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAAVFGDGQVKEPVPTMALGEPDPKAQ
TGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHEL
LNA
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function May play a role in neurotransmitter secretion.
TTD ID
T22284
Uniprot ID
Q05084
DrugMap ID
TTMX06B
Ensemble ID
ENST00000265577.11
HGNC ID
HGNC:5343

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.Q81E .
IM95 SNV: p.L184I DBIA    Probe Info 
JHH1 SNV: p.T237N .
JURKAT SNV: p.T33A; p.E93D .
KYSE180 SNV: p.M173I .
MOLT4 SNV: p.L481I .
NCIH2172 SNV: p.L376F .
NCIH3122 SNV: p.C121Ter .
SW403 SNV: p.A148P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y185(18.51)  LDD3495  [2]
DBIA
 Probe Info  		C85(9.30)  LDD0209  [3]
IA-alkyne
 Probe Info  		C70(0.00); C85(0.00); C224(0.00)  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
NAIA_5
 Probe Info  		C224(0.00); C135(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C121(0.91); C224(1.03)  LDD1513  [7]
 LDCM0283  AC23 HEK-293T C121(0.89); C224(0.93)  LDD1522  [7]
 LDCM0292  AC31 HEK-293T C121(0.95); C224(1.12)  LDD1531  [7]
 LDCM0300  AC39 HEK-293T C121(0.98); C224(0.99)  LDD1539  [7]
 LDCM0309  AC47 HEK-293T C121(1.09); C224(1.02)  LDD1548  [7]
 LDCM0318  AC55 HEK-293T C121(0.99); C224(1.02)  LDD1557  [7]
 LDCM0327  AC63 HEK-293T C121(0.93); C224(1.08)  LDD1566  [7]
 LDCM0334  AC7 HEK-293T C121(0.97); C224(1.06)  LDD1568  [7]
 LDCM0156  Aniline NCI-H1299 11.59  LDD0403  [1]
 LDCM0369  CL100 HEK-293T C121(0.98); C70(1.04)  LDD1573  [7]
 LDCM0371  CL102 HEK-293T C121(1.02)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C121(1.05); C70(1.03)  LDD1577  [7]
 LDCM0375  CL106 HEK-293T C121(0.99)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C121(0.94); C70(0.94)  LDD1581  [7]
 LDCM0379  CL11 HEK-293T C121(0.91); C224(1.15)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C121(1.03)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C121(0.90); C70(0.99)  LDD1586  [7]
 LDCM0384  CL114 HEK-293T C121(1.07)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C121(1.01); C70(1.10)  LDD1590  [7]
 LDCM0388  CL118 HEK-293T C121(1.38)  LDD1592  [7]
 LDCM0391  CL120 HEK-293T C121(1.03); C70(1.08)  LDD1595  [7]
 LDCM0393  CL122 HEK-293T C121(1.07)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C121(1.06); C70(1.09)  LDD1599  [7]
 LDCM0397  CL126 HEK-293T C121(0.97)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C121(1.06); C70(1.03)  LDD1603  [7]
 LDCM0401  CL14 HEK-293T C121(1.07)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C121(1.02); C70(0.98)  LDD1607  [7]
 LDCM0407  CL2 HEK-293T C121(0.92)  LDD1611  [7]
 LDCM0411  CL23 HEK-293T C121(1.00); C224(0.97)  LDD1615  [7]
 LDCM0414  CL26 HEK-293T C121(1.13)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C121(1.11); C70(0.97)  LDD1620  [7]
 LDCM0424  CL35 HEK-293T C121(1.02); C224(0.88)  LDD1628  [7]
 LDCM0429  CL4 HEK-293T C121(1.07); C70(1.08)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C121(0.97); C70(0.97)  LDD1634  [7]
 LDCM0437  CL47 HEK-293T C121(1.06); C224(0.85)  LDD1641  [7]
 LDCM0441  CL50 HEK-293T C121(1.05)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C121(1.17); C70(1.08)  LDD1646  [7]
 LDCM0450  CL59 HEK-293T C121(1.06); C224(0.95)  LDD1653  [7]
 LDCM0454  CL62 HEK-293T C121(1.16)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C121(1.12); C70(0.98)  LDD1659  [7]
 LDCM0464  CL71 HEK-293T C121(0.97); C224(1.15)  LDD1667  [7]
 LDCM0467  CL74 HEK-293T C121(0.99)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C121(1.03); C70(1.10)  LDD1672  [7]
 LDCM0477  CL83 HEK-293T C121(1.05); C224(1.13)  LDD1680  [7]
 LDCM0480  CL86 HEK-293T C121(1.04)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C121(0.99); C70(1.03)  LDD1685  [7]
 LDCM0490  CL95 HEK-293T C121(1.01); C224(1.33)  LDD1693  [7]
 LDCM0493  CL98 HEK-293T C121(1.07)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C121(0.97)  LDD1631  [7]
 LDCM0022  KB02 AGS C70(2.34)  LDD2263  [8]
 LDCM0023  KB03 Jurkat C85(9.30)  LDD0209  [3]
 LDCM0024  KB05 NCI-N87 C70(5.08)  LDD3364  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-2A (RAB2A) Rab family P61019
Ras-related protein Rab-2B (RAB2B) Rab family Q8WUD1
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Coiled-coil domain-containing protein 28A (CCDC28A) . Q8IWP9
Methyl-CpG-binding domain protein 3 (MBD3) . O95983
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840