Details of the Target

General Information of Target

Target ID LDTP05414
Target Name Heat shock factor protein 2 (HSF2)
Gene Name HSF2
Gene ID 3298
Synonyms
HSTF2; Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS
FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK
IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ
FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE
RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ
SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL
LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK
NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP
IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS
Target Bioclass
Transcription factor
Family
HSF family
Subcellular location
Cytoplasm
Function DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Uniprot ID
Q03933
Ensemble ID
ENST00000368455.9
HGNC ID
HGNC:5225
ChEMBL ID
CHEMBL3988631

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.I247T .
Ishikawa (Heraklio) 02 ER SNV: p.A59V .
JURKAT SNV: p.G87S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C369(1.11)  LDD1511  [1]
HHS-465
 Probe Info  		K97(0.00); Y95(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C369(1.01)  LDD1520  [1]
 LDCM0284  AC24 HEK-293T C369(0.99)  LDD1523  [1]
 LDCM0289  AC29 HEK-293T C369(1.08)  LDD1528  [1]
 LDCM0293  AC32 HEK-293T C369(0.86)  LDD1532  [1]
 LDCM0298  AC37 HEK-293T C369(1.17)  LDD1537  [1]
 LDCM0302  AC40 HEK-293T C369(0.82)  LDD1541  [1]
 LDCM0307  AC45 HEK-293T C369(1.04)  LDD1546  [1]
 LDCM0310  AC48 HEK-293T C369(1.84)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C369(1.05)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C369(1.05)  LDD1555  [1]
 LDCM0319  AC56 HEK-293T C369(1.26)  LDD1558  [1]
 LDCM0325  AC61 HEK-293T C369(1.02)  LDD1564  [1]
 LDCM0328  AC64 HEK-293T C369(0.93)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C369(0.93)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C369(1.11)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C369(1.13)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C369(0.85)  LDD1594  [1]
 LDCM0409  CL21 HEK-293T C369(1.14)  LDD1613  [1]
 LDCM0412  CL24 HEK-293T C369(1.00)  LDD1616  [1]
 LDCM0422  CL33 HEK-293T C369(1.97)  LDD1626  [1]
 LDCM0425  CL36 HEK-293T C369(0.97)  LDD1629  [1]
 LDCM0435  CL45 HEK-293T C369(1.18)  LDD1639  [1]
 LDCM0438  CL48 HEK-293T C369(1.09)  LDD1642  [1]
 LDCM0448  CL57 HEK-293T C369(1.16)  LDD1651  [1]
 LDCM0452  CL60 HEK-293T C369(1.02)  LDD1655  [1]
 LDCM0461  CL69 HEK-293T C369(1.61)  LDD1664  [1]
 LDCM0465  CL72 HEK-293T C369(0.94)  LDD1668  [1]
 LDCM0475  CL81 HEK-293T C369(1.08)  LDD1678  [1]
 LDCM0478  CL84 HEK-293T C369(1.27)  LDD1681  [1]
 LDCM0484  CL9 HEK-293T C369(0.92)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C369(1.08)  LDD1691  [1]
 LDCM0491  CL96 HEK-293T C369(0.85)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010