Details of the Target

General Information of Target

Target ID LDTP05336
Target Name Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)
Gene Name GUCY1A1
Gene ID 2982
Synonyms
GUC1A3; GUCSA3; GUCY1A3; Guanylate cyclase soluble subunit alpha-1; GCS-alpha-1; EC 4.6.1.2; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; Soluble guanylate cyclase large subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
Target Bioclass
Enzyme
Family
Adenylyl cyclase class-4/guanylyl cyclase family
Subcellular location
Cytoplasm
Uniprot ID
Q02108
Ensemble ID
ENST00000296518.11
HGNC ID
HGNC:4685
ChEMBL ID
CHEMBL3137281

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A659V DBIA    Probe Info 
HCT15 SNV: p.L559F .
HSC3 SNV: p.G126A .
HT SNV: p.S280P .
NCIH1975 SNV: p.Q501R .
NCIH1993 SNV: p.M1? .
NCIH2170 SNV: p.K433N .
NCIH2172 SNV: p.A75S; p.R593L .
NCIH446 SNV: p.K433Q .
SKMEL24 SNV: p.D313N .
SNGM SNV: p.K294N .
SNU1 Deletion: p.G537DfsTer13; p.K627RfsTer21 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C610(1.83)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C79(0.98)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C610(0.91)  LDD1523  [2]
 LDCM0289  AC29 HEK-293T C79(1.00)  LDD1528  [2]
 LDCM0293  AC32 HEK-293T C610(0.83)  LDD1532  [2]
 LDCM0298  AC37 HEK-293T C79(1.02)  LDD1537  [2]
 LDCM0302  AC40 HEK-293T C610(0.91)  LDD1541  [2]
 LDCM0307  AC45 HEK-293T C79(1.04)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C610(0.94)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C79(0.96)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C79(1.06)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C610(0.85)  LDD1558  [2]
 LDCM0325  AC61 HEK-293T C79(1.03)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C610(0.88)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C610(1.09)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C79(1.05)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C610(0.97)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C79(0.79)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C79(0.80)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C79(0.92)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C79(1.07)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C79(0.88)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C79(0.94)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C79(0.84)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C79(1.31)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C79(0.96)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C79(1.31)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C79(0.80)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C79(0.97)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C79(1.38)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C79(0.90)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C79(0.87)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C79(1.27)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C610(1.36)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C79(0.86)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C79(1.07)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C79(0.91)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C79(0.84)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C79(0.99)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C79(0.99)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C79(1.18)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C79(0.97)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C79(1.05)  LDD1606  [2]
 LDCM0407  CL2 HEK-293T C79(0.97)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C79(0.94)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C610(0.88)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C79(0.79)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C79(0.98)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C79(0.94)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C79(0.94)  LDD1622  [2]
 LDCM0422  CL33 HEK-293T C79(0.85)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C610(0.75)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C79(0.84)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C79(1.09)  LDD1632  [2]
 LDCM0435  CL45 HEK-293T C79(0.93)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C610(1.10)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C79(1.02)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C79(1.12)  LDD1645  [2]
 LDCM0448  CL57 HEK-293T C79(0.92)  LDD1651  [2]
 LDCM0452  CL60 HEK-293T C610(1.15)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C79(0.96)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C79(0.91)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C79(1.04)  LDD1658  [2]
 LDCM0461  CL69 HEK-293T C79(1.04)  LDD1664  [2]
 LDCM0465  CL72 HEK-293T C610(0.97)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C79(0.95)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C79(0.93)  LDD1670  [2]
 LDCM0475  CL81 HEK-293T C79(0.95)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C610(0.93)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C79(1.19)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C79(1.06)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C79(0.83)  LDD1684  [2]
 LDCM0484  CL9 HEK-293T C79(1.07)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C79(1.00)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C610(0.83)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C79(0.83)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C79(1.18)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C79(1.15)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C79(0.90)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C79(0.95)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C79(1.07)  LDD1631  [2]
 LDCM0022  KB02 786-O C610(1.48)  LDD2247  [1]
 LDCM0023  KB03 769-P C610(1.63)  LDD2663  [1]
 LDCM0024  KB05 NB1 C610(1.83)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402