Details of the Target

General Information of Target

Target ID LDTP05080
Target Name Hemoglobin subunit beta (HBB)
Gene Name HBB
Gene ID 3043
Synonyms
Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG
KEFTPPVQAAYQKVVAGVANALAHKYH
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Globin family
Function
Involved in oxygen transport from the lung to the various peripheral tissues.; LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
TTD ID
T31825
Uniprot ID
P68871
DrugMap ID
TTM6HK1
Ensemble ID
ENST00000335295.4
HGNC ID
HGNC:4827
ChEMBL ID
CHEMBL4331

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD2242  [1]
Acrolein
 Probe Info  		H98(0.00); C94(0.00)  LDD0217  [2]
TER-AC
 Probe Info  		N.A.  LDD0426  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe15
 Probe Info  		20.00  LDD0478  [4]
FFF probe2
 Probe Info  		20.00  LDD0463  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H98(0.00); C94(0.00)  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit alpha (HBA1; HBA2) Globin family P69905
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit mu (HBM) Globin family Q6B0K9
Hemoglobin subunit theta-1 (HBQ1) Globin family P09105
Hemoglobin subunit zeta (HBZ) Globin family P02008

The Drug(s) Related To This Target

Approved
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iron Dextran Small molecular drug DB00893
Pentaerythritol Tetranitrate Small molecular drug DB06154
Copper . DB09130
Ferric Pyrophosphate Citrate . DB13995
Nitrous Acid . DB09112
Oxygen . DB09140
Sodium Ferric Gluconate Complex . DB09517
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lentiglobin . D0C9LQ
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Otl-300 Gene therapy D1RMS5
Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-[(2-methoxy-5-methylphenoxy)Methyl]Pyridine Small molecular drug DB07427
26-dicarboxynaphthalene Small molecular drug DB08262
4-[(5-methoxy-2-methylphenoxy)Methyl]Pyridine Small molecular drug DB07428
Efaproxiral Small molecular drug DB08486
Ferric Pyrophosphate Small molecular drug DB09147
Sebacic Acid Small molecular drug DB07645
Trimesic Acid Small molecular drug DB08632
2-[4-({[(35-dichlorophenyl)Amino]Carbonyl}Amino)Phenoxy]-2-methylpropanoic Acid . DB08077
4-carboxycinnamic Acid . DB02126

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.