Details of the Target

General Information of Target

Target ID LDTP04522
Target Name Zinc finger protein 140 (ZNF140)
Gene Name ZNF140
Gene ID 7699
Synonyms
Zinc finger protein 140
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQGSVTFRDVAIDFSQEEWKWLQPAQRDLYRCVMLENYGHLVSLGLSISKPDVVSLLEQ
GKEPWLGKREVKRDLFSVSESSGEIKDFSPKNVIYDDSSQYLIMERILSQGPVYSSFKGG
WKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERPYGCHECGKTFGRRFSLVLHQ
RTHTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIEHQRTHT
GEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKP
YECIECGKAFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECD
ECGKVFTWHASLIQHTKSHTGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKVCNK
SFSWSSNLAKHQRTHTLDNPYEYENSFNYHSFLTEHQ
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation as a repressor.
Uniprot ID
P52738
Ensemble ID
ENST00000355557.7
HGNC ID
HGNC:12925

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.N92MfsTer11 .
A431 SNV: p.H267Y .
HT115 SNV: p.R349I .
NCIH1155 SNV: p.E70K .
NCIH1792 SNV: p.Y273N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C340(1.01)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C340(1.01)  LDD1507  [1]
 LDCM0226  AC11 HEK-293T C340(1.12)  LDD1509  [1]
 LDCM0276  AC17 HEK-293T C340(0.94)  LDD1515  [1]
 LDCM0278  AC19 HEK-293T C340(1.33)  LDD1517  [1]
 LDCM0284  AC24 HEK-293T C340(1.05)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C340(1.12)  LDD1524  [1]
 LDCM0287  AC27 HEK-293T C340(1.10)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C340(1.07)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C340(0.93)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C340(1.13)  LDD1533  [1]
 LDCM0296  AC35 HEK-293T C340(1.12)  LDD1535  [1]
 LDCM0302  AC40 HEK-293T C340(1.07)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C340(1.16)  LDD1542  [1]
 LDCM0305  AC43 HEK-293T C340(1.09)  LDD1544  [1]
 LDCM0310  AC48 HEK-293T C340(1.04)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C340(1.26)  LDD1550  [1]
 LDCM0314  AC51 HEK-293T C340(1.19)  LDD1553  [1]
 LDCM0319  AC56 HEK-293T C340(1.10)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C340(0.87)  LDD1559  [1]
 LDCM0322  AC59 HEK-293T C340(1.21)  LDD1561  [1]
 LDCM0328  AC64 HEK-293T C340(1.06)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C340(1.21)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C340(0.96)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C340(0.85)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C340(1.04)  LDD1594  [1]
 LDCM0404  CL17 HEK-293T C340(0.76)  LDD1608  [1]
 LDCM0406  CL19 HEK-293T C340(1.55)  LDD1610  [1]
 LDCM0412  CL24 HEK-293T C340(1.11)  LDD1616  [1]
 LDCM0417  CL29 HEK-293T C340(1.02)  LDD1621  [1]
 LDCM0420  CL31 HEK-293T C340(1.27)  LDD1624  [1]
 LDCM0425  CL36 HEK-293T C340(0.85)  LDD1629  [1]
 LDCM0431  CL41 HEK-293T C340(0.98)  LDD1635  [1]
 LDCM0433  CL43 HEK-293T C340(1.17)  LDD1637  [1]
 LDCM0438  CL48 HEK-293T C340(1.05)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C340(0.81)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C340(1.07)  LDD1647  [1]
 LDCM0446  CL55 HEK-293T C340(1.14)  LDD1649  [1]
 LDCM0452  CL60 HEK-293T C340(0.98)  LDD1655  [1]
 LDCM0457  CL65 HEK-293T C340(0.96)  LDD1660  [1]
 LDCM0459  CL67 HEK-293T C340(1.13)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C340(1.08)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C340(1.33)  LDD1668  [1]
 LDCM0470  CL77 HEK-293T C340(0.99)  LDD1673  [1]
 LDCM0472  CL79 HEK-293T C340(1.23)  LDD1675  [1]
 LDCM0478  CL84 HEK-293T C340(0.98)  LDD1681  [1]
 LDCM0483  CL89 HEK-293T C340(0.93)  LDD1686  [1]
 LDCM0486  CL91 HEK-293T C340(1.09)  LDD1689  [1]
 LDCM0491  CL96 HEK-293T C340(1.15)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402