Details of the Target

General Information of Target

Target ID LDTP04378
Target Name Tubby protein homolog (TUB)
Gene Name TUB
Gene ID 7275
Synonyms
Tubby protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR
ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG
GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD
LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP
EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA
GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES
GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE
SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM
DYNYPLCALQAFAIALSSFDSKLACE
Target Bioclass
Other
Family
TUB family
Subcellular location
Cytoplasm
Function
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
Uniprot ID
P50607
Ensemble ID
ENST00000299506.3
HGNC ID
HGNC:12406

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.P258S .
HCT116 Deletion: p.L70WfsTer85 .
HSC4 SNV: p.A114D .
HT115 SNV: p.G460D .
MCC13 SNV: p.L181F .
NCIH1155 SNV: p.R333W .
SNU1 Deletion: p.L70WfsTer85 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C426(1.19)  LDD3395  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C371(1.21)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C371(1.00)  LDD1513  [2]
 LDCM0280  AC20 HEK-293T C371(1.06)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C371(1.00)  LDD1522  [2]
 LDCM0288  AC28 HEK-293T C371(1.13)  LDD1527  [2]
 LDCM0292  AC31 HEK-293T C371(0.94)  LDD1531  [2]
 LDCM0297  AC36 HEK-293T C371(1.20)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C371(1.09)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C371(1.14)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C371(1.21)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C371(1.04)  LDD1548  [2]
 LDCM0315  AC52 HEK-293T C371(1.22)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C371(0.91)  LDD1557  [2]
 LDCM0324  AC60 HEK-293T C371(1.09)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C371(0.96)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C371(1.04)  LDD1568  [2]
 LDCM0379  CL11 HEK-293T C371(0.97)  LDD1583  [2]
 LDCM0408  CL20 HEK-293T C371(1.11)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C371(1.15)  LDD1615  [2]
 LDCM0421  CL32 HEK-293T C371(1.17)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C371(0.91)  LDD1628  [2]
 LDCM0434  CL44 HEK-293T C371(1.11)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C371(1.05)  LDD1641  [2]
 LDCM0447  CL56 HEK-293T C371(1.12)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C371(1.26)  LDD1653  [2]
 LDCM0460  CL68 HEK-293T C371(1.12)  LDD1663  [2]
 LDCM0464  CL71 HEK-293T C371(0.98)  LDD1667  [2]
 LDCM0473  CL8 HEK-293T C371(0.90)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C371(1.22)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C371(1.06)  LDD1680  [2]
 LDCM0487  CL92 HEK-293T C371(1.17)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C371(0.88)  LDD1693  [2]
 LDCM0022  KB02 Caov-3 C426(1.15)  LDD2295  [1]
 LDCM0023  KB03 Caov-3 C426(1.44)  LDD2712  [1]
 LDCM0024  KB05 PC-3 C426(1.19)  LDD3395  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402