Details of the Target

General Information of Target

Target ID LDTP04343
Target Name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)
Gene Name GNG4
Gene ID 2786
Synonyms
GNGT4; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPA
SENPFREKKFFCTIL
Target Bioclass
Other
Family
G protein gamma family
Subcellular location
Cell membrane
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot ID
P50150
Ensemble ID
ENST00000366597.5
HGNC ID
HGNC:4407

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C28(1.12)  LDD3331  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C28(1.09)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C28(1.14)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C28(1.11); C45(0.62)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C28(0.92)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C28(1.17)  LDD1517  [3]
 LDCM0281  AC21 HEK-293T C28(0.84); C45(0.81)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C28(1.12); C45(0.74)  LDD1521  [3]
 LDCM0285  AC25 HEK-293T C28(1.03)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C28(1.26)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C28(0.91); C45(0.76)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C28(1.07)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C28(1.41); C45(0.69)  LDD1530  [3]
 LDCM0294  AC33 HEK-293T C28(1.09)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C28(1.06)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C28(1.06); C45(0.73)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C28(1.17); C45(0.66)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C28(1.07)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C28(1.23)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C28(1.27); C45(0.66)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C28(1.13); C45(0.71)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C28(1.19)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C28(0.87); C45(0.83)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C28(1.20)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C28(1.06); C45(0.70)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C28(1.09); C45(0.58)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C28(1.29)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C28(1.23)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C28(1.11); C45(0.84)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C28(1.11); C45(0.97)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C28(1.29); C45(0.77)  LDD1565  [3]
 LDCM0248  AKOS034007472 HEK-293T C28(1.04); C45(0.90)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C28(1.07)  LDD1570  [3]
 LDCM0367  CL1 HEK-293T C28(1.25)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C28(0.97); C45(1.70)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C28(1.26)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C28(0.95)  LDD1574  [3]
 LDCM0373  CL104 HEK-293T C28(1.13)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C28(1.20)  LDD1578  [3]
 LDCM0377  CL108 HEK-293T C28(1.36)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C28(1.16)  LDD1582  [3]
 LDCM0382  CL112 HEK-293T C28(1.04)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C28(1.41)  LDD1587  [3]
 LDCM0386  CL116 HEK-293T C28(1.17)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C28(1.37)  LDD1591  [3]
 LDCM0391  CL120 HEK-293T C28(1.51)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C28(1.19)  LDD1596  [3]
 LDCM0395  CL124 HEK-293T C28(1.22)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C28(1.23)  LDD1600  [3]
 LDCM0399  CL128 HEK-293T C28(1.38)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C28(1.15)  LDD1604  [3]
 LDCM0403  CL16 HEK-293T C28(0.94)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C28(0.91)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C28(0.99)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C28(1.16); C45(0.99)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C28(1.34); C45(0.72)  LDD1614  [3]
 LDCM0413  CL25 HEK-293T C28(0.94)  LDD1617  [3]
 LDCM0416  CL28 HEK-293T C28(1.18)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C28(0.97)  LDD1621  [3]
 LDCM0420  CL31 HEK-293T C28(0.96)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C28(0.91); C45(1.01)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C28(1.24); C45(0.68)  LDD1627  [3]
 LDCM0426  CL37 HEK-293T C28(1.11)  LDD1630  [3]
 LDCM0429  CL4 HEK-293T C28(1.05)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C28(1.15)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C28(1.24)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C28(1.32)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C28(1.03); C45(0.78)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C28(1.32); C45(0.78)  LDD1640  [3]
 LDCM0439  CL49 HEK-293T C28(1.05)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C28(0.90)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C28(1.39)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C28(1.03)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C28(1.31)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C28(1.11); C45(0.80)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C28(1.20); C45(0.47)  LDD1652  [3]
 LDCM0453  CL61 HEK-293T C28(0.99)  LDD1656  [3]
 LDCM0456  CL64 HEK-293T C28(1.25)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C28(1.07)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C28(1.31)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C28(1.01); C45(0.77)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C28(1.15)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C28(1.35); C45(0.66)  LDD1666  [3]
 LDCM0466  CL73 HEK-293T C28(1.23)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C28(1.25)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C28(1.04)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C28(1.07)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C28(1.06); C45(0.66)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C28(1.32); C45(0.61)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C28(1.09)  LDD1682  [3]
 LDCM0482  CL88 HEK-293T C28(1.33)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C28(1.22)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C28(1.04); C45(1.16)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C28(1.22)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C28(0.99); C45(0.84)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C28(1.32); C45(0.71)  LDD1692  [3]
 LDCM0492  CL97 HEK-293T C28(1.19)  LDD1695  [3]
 LDCM0022  KB02 22RV1 C28(1.08)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C28(1.29)  LDD2660  [2]
 LDCM0024  KB05 MKN-1 C28(1.12)  LDD3331  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402