Details of the Target

General Information of Target

Target ID LDTP03897
Target Name Pre-B-cell leukemia transcription factor 2 (PBX2)
Gene Name PBX2
Gene ID 5089
Synonyms
G17; Pre-B-cell leukemia transcription factor 2; Homeobox protein PBX2; Protein G17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDERLLGPPPPGGGRGGLGLVSGEPGGPGEPPGGGDPGGGSGGVPGGRGKQDIGDILQQI
MTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDN
MLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRHIYHSELEKYE
QACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVMILRSR
FLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRI
RYKKNIGKFQEEANIYAVKTAVSVTQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMP
GLNGDSYSASQVESLRHSMGPGGYGDNLGGGQMYSPREMRANGSWQEAVTPSSVTSPTEG
PGSVHSDTSN
Target Bioclass
Transcription factor
Family
TALE/PBX homeobox family
Subcellular location
Nucleus
Function Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.
Uniprot ID
P40425
Ensemble ID
ENST00000375050.6
HGNC ID
HGNC:8633

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y264(7.62)  LDD0257  [1]
DBIA
 Probe Info  		C80(3.44)  LDD3311  [2]
HHS-475
 Probe Info  		Y262(0.92)  LDD0264  [3]
IA-alkyne
 Probe Info  		C183(0.00); C231(0.00); C284(0.00)  LDD0165  [4]
IPM
 Probe Info  		C231(0.00); C80(0.00)  LDD2156  [5]
AOyne
 Probe Info  		12.10  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C231(0.82)  LDD1093  [7]
 LDCM0279  AC2 PaTu 8988t C231(1.17)  LDD1158  [7]
 LDCM0290  AC3 PaTu 8988t C231(0.77)  LDD1169  [7]
 LDCM0296  AC35 PaTu 8988t C231(0.89)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C231(0.94)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C231(1.14)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C231(0.99)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C231(0.90)  LDD1179  [7]
 LDCM0301  AC4 PaTu 8988t C231(0.95)  LDD1180  [7]
 LDCM0302  AC40 PaTu 8988t C231(1.09)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C231(0.81)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C231(1.11)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C231(1.06)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C231(1.18)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C231(1.27)  LDD1186  [7]
 LDCM0312  AC5 PaTu 8988t C231(1.12)  LDD1191  [7]
 LDCM0369  CL100 PaTu 8988t C231(0.84)  LDD1248  [7]
 LDCM0387  CL117 PaTu 8988t C231(0.90)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C231(1.38)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C231(1.63)  LDD1268  [7]
 LDCM0391  CL120 PaTu 8988t C231(0.84)  LDD1270  [7]
 LDCM0403  CL16 PaTu 8988t C231(0.74)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C231(0.65)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C231(0.55)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C231(0.89)  LDD1285  [7]
 LDCM0408  CL20 PaTu 8988t C231(0.86)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C231(0.83)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C231(0.75)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C231(1.72)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C231(0.83)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C231(0.82)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C231(0.78)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C231(0.87)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C231(1.26)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C231(0.73)  LDD1296  [7]
 LDCM0419  CL30 PaTu 8988t C231(0.85)  LDD1298  [7]
 LDCM0420  CL31 PaTu 8988t C231(1.10)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C231(0.97)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C231(1.16)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C231(1.04)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C231(1.61)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C231(0.66)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C231(0.99)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C231(1.03)  LDD1307  [7]
 LDCM0430  CL40 PaTu 8988t C231(0.96)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C231(1.14)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C231(1.73)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C231(1.04)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C231(1.21)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C231(1.17)  LDD1314  [7]
 LDCM0453  CL61 PaTu 8988t C231(0.84)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C231(1.08)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C231(1.26)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C231(0.80)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C231(0.68)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C231(0.89)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C231(0.88)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C231(0.85)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C231(1.23)  LDD1340  [7]
 LDCM0463  CL70 PaTu 8988t C231(0.86)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C231(0.75)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C231(0.92)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C231(0.92)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C231(0.80)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C231(1.07)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C231(0.79)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C231(1.05)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C231(1.09)  LDD1351  [7]
 LDCM0474  CL80 PaTu 8988t C231(1.47)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C231(1.11)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C231(0.77)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C231(1.00)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C231(1.28)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C231(0.95)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C231(1.03)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C231(1.25)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C231(1.23)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C231(0.79)  LDD1362  [7]
 LDCM0485  CL90 PaTu 8988t C231(0.91)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C231(0.81)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C231(0.84)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C231(1.23)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C231(0.81)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C231(0.94)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C231(1.33)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C231(1.47)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C231(1.31)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C231(0.92)  LDD1373  [7]
 LDCM0468  Fragment33 PaTu 8988t C231(0.82)  LDD1347  [7]
 LDCM0427  Fragment51 PaTu 8988t C231(1.19)  LDD1306  [7]
 LDCM0116  HHS-0101 DM93 Y262(0.92)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y262(2.51)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y262(0.61)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y262(2.73)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y262(1.25); Y264(1.28)  LDD0268  [3]
 LDCM0022  KB02 697 C80(2.02)  LDD2245  [2]
 LDCM0023  KB03 697 C80(1.82)  LDD2662  [2]
 LDCM0024  KB05 G361 C80(3.44)  LDD3311  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C9 (HOXC9) Abd-B homeobox family P31274
Homeobox protein Hox-A5 (HOXA5) Antp homeobox family P20719
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Musculin (MSC) . O60682
T-cell leukemia homeobox protein 1 (TLX1) . P31314
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) BRMS1 family Q5PSV4
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Phakinin (BFSP2) Intermediate filament family Q13515
Liprin-beta-1 (PPFIBP1) Liprin family Q86W92
Protein ripply2 (RIPPLY2) Ripply family Q5TAB7
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Zinc finger CW-type PWWP domain protein 2 (ZCWPW2) . Q504Y3

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.