Details of the Target

General Information of Target

Target ID LDTP03693
Target Name Tyrosine-protein kinase RYK (RYK)
Gene Name RYK
Gene ID 6259
Synonyms
JTK5A; Tyrosine-protein kinase RYK; EC 2.7.10.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPT
LRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQ
AFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLK
LFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVK
ITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQ
TPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFH
AALGAYV
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family
Subcellular location
Membrane
Function
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Uniprot ID
P34925
Ensemble ID
ENST00000620660.4
HGNC ID
HGNC:10481

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC3 SNV: p.R424Ter .
RL SNV: p.E358Ter .
SNU1 SNV: p.L592P .
SNU869 SNV: p.A60S .
SW620 SNV: p.R212K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C598(1.63)  LDD3351  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C471(1.08)  LDD1507  [2]
 LDCM0259  AC14 HEK-293T C471(1.25)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C471(1.00)  LDD1515  [2]
 LDCM0281  AC21 HEK-293T C471(1.07)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C471(1.01)  LDD1521  [2]
 LDCM0285  AC25 HEK-293T C471(1.13)  LDD1524  [2]
 LDCM0289  AC29 HEK-293T C471(1.12)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C471(0.90)  LDD1530  [2]
 LDCM0294  AC33 HEK-293T C471(1.05)  LDD1533  [2]
 LDCM0298  AC37 HEK-293T C471(1.16)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C471(0.96)  LDD1538  [2]
 LDCM0303  AC41 HEK-293T C471(1.12)  LDD1542  [2]
 LDCM0307  AC45 HEK-293T C471(1.38)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C471(0.86)  LDD1547  [2]
 LDCM0311  AC49 HEK-293T C471(1.17)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C471(1.24)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C471(1.27)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C471(1.01)  LDD1556  [2]
 LDCM0320  AC57 HEK-293T C471(1.05)  LDD1559  [2]
 LDCM0323  AC6 HEK-293T C471(1.06)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C471(1.07)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C471(0.93)  LDD1565  [2]
 LDCM0248  AKOS034007472 HEK-293T C471(1.20)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C471(1.09)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C471(1.07); C595(0.69)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C471(1.06)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C471(0.94)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C471(1.08); C595(1.17)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C471(1.03)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C471(0.93)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C471(1.13); C595(1.12)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C471(1.05)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C471(0.94)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C471(1.06); C595(0.98)  LDD1582  [2]
 LDCM0381  CL111 HEK-293T C471(1.05)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C471(0.94)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C471(0.89); C595(1.00)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C471(0.99)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C471(0.92)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C471(1.04); C595(1.07)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C471(1.10)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C471(1.15)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C471(1.16); C595(0.90)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C471(1.45)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C471(0.80)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C471(1.10); C595(1.14)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C471(1.05)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C471(0.81)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C471(1.23); C595(1.03)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C471(1.43)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C471(0.92)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C471(1.20)  LDD1608  [2]
 LDCM0409  CL21 HEK-293T C471(1.17)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C471(1.10)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C471(1.40); C595(1.11)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C471(1.01)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C471(0.80)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C471(0.99)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C471(0.88)  LDD1622  [2]
 LDCM0422  CL33 HEK-293T C471(1.83)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C471(1.02)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C471(0.98); C595(1.02)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C471(1.10)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C471(0.89)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C471(0.90)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C471(1.21)  LDD1635  [2]
 LDCM0435  CL45 HEK-293T C471(1.14)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C471(1.01)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C471(1.15); C595(0.88)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C471(1.08)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C471(1.06)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C471(0.89)  LDD1647  [2]
 LDCM0448  CL57 HEK-293T C471(1.66)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C471(0.96)  LDD1652  [2]
 LDCM0453  CL61 HEK-293T C471(0.93); C595(1.38)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C471(1.01)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C471(1.10)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C471(1.13)  LDD1660  [2]
 LDCM0461  CL69 HEK-293T C471(1.48)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C471(1.33)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C471(1.43); C595(0.81)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C471(0.88)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C471(1.30)  LDD1673  [2]
 LDCM0475  CL81 HEK-293T C471(1.30)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C471(1.06)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C471(0.99); C595(1.05)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C471(1.30)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C471(0.83)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C471(1.26)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C471(1.19)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C471(1.45)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C471(0.97)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C471(0.94); C595(0.82)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C471(1.05)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C471(1.23)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C471(1.22)  LDD1671  [2]
 LDCM0022  KB02 A375.S2 C598(2.16)  LDD2256  [1]
 LDCM0023  KB03 A101D C598(1.83)  LDD2667  [1]
 LDCM0024  KB05 NCI-H196 C598(1.63)  LDD3351  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402