Details of the Target

General Information of Target

Target ID LDTP03632
Target Name Homeobox protein OTX1 (OTX1)
Gene Name OTX1
Gene ID 5013
Synonyms
Homeobox protein OTX1; Orthodenticle homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKT
RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSG
SESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPA
SISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSS
SYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHH
HQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL
Target Bioclass
Transcription factor
Family
Paired homeobox family, Bicoid subfamily
Subcellular location
Nucleus
Function Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Uniprot ID
P32242
Ensemble ID
ENST00000282549.7
HGNC ID
HGNC:8521

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C340(0.75)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C340(0.91)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C340(0.90)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C340(1.15)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C340(0.99)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C340(0.95)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C340(1.01)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C340(0.77)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C340(0.93)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C340(0.89)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C340(1.06)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C340(1.01)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C340(0.99)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C340(1.02)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C340(1.00)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C340(0.96)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C340(1.18)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C340(1.15)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C340(0.98)  LDD1604  [1]
 LDCM0412  CL24 HEK-293T C340(0.87)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C340(0.81)  LDD1617  [1]
 LDCM0425  CL36 HEK-293T C340(1.03)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C340(1.07)  LDD1630  [1]
 LDCM0438  CL48 HEK-293T C340(1.13)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C340(0.86)  LDD1643  [1]
 LDCM0452  CL60 HEK-293T C340(0.83)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C340(1.32)  LDD1656  [1]
 LDCM0465  CL72 HEK-293T C340(1.07)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C340(0.99)  LDD1669  [1]
 LDCM0478  CL84 HEK-293T C340(0.85)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C340(0.82)  LDD1682  [1]
 LDCM0491  CL96 HEK-293T C340(0.80)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C340(0.93)  LDD1695  [1]
 LDCM0022  KB02 HEK-293T C340(0.75)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C340(1.13)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C340(0.99)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402