Details of the Target

General Information of Target

Target ID LDTP03588
Target Name T-cell leukemia homeobox protein 1 (TLX1)
Gene Name TLX1
Gene ID 3195
Synonyms
HOX11; TCL3; T-cell leukemia homeobox protein 1; Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG
GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS
GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN
RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM
TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN
SSLFALQNLQPWSDDSTKITSVTSVASACE
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Uniprot ID
P31314
Ensemble ID
ENST00000370196.11
HGNC ID
HGNC:5056

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.A227D .
COLO792 SNV: p.G114S .
CORL23 SNV: p.A266S .
HCT116 SNV: p.G118S .
HCT15 SNV: p.G118S .
HUH7 Substitution: p.L154_P155delinsFS .
IPC298 SNV: p.H10Y .
NALM6 SNV: p.T156P .
NCIH716 SNV: p.Q270E .
REH SNV: p.R222C .
SKNSH SNV: p.T156P .
SNU5 SNV: p.G31A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C214(1.23)  LDD2229  [1]
BTD
 Probe Info  		C214(0.97)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C297(2.30); C214(2.20)  LDD0169  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C214(1.08)  LDD2112  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C214(0.95)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C214(0.94)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C214(1.19)  LDD2152  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C214(0.76)  LDD2131  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C297(2.30); C214(2.20)  LDD0169  [3]
 LDCM0498  BS-3668 MDA-MB-231 C214(0.88)  LDD2091  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C214(1.00)  LDD2102  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C214(0.98)  LDD2093  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C214(0.98)  LDD2098  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C214(0.85)  LDD2100  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C214(1.04)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C214(1.38)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C214(0.82)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C214(0.94)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C214(0.95)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C214(1.12)  LDD2109  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C214(1.86)  LDD2110  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C214(0.70)  LDD2114  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C214(1.37)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C214(0.98)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C214(1.54)  LDD2124  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C214(0.99)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C214(1.06)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C214(0.97)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C214(1.01)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C214(0.62)  LDD2141  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C214(0.85)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C214(5.85)  LDD2145  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C214(0.96)  LDD2146  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Meis1 (MEIS1) TALE/MEIS homeobox family O00470
Pre-B-cell leukemia transcription factor 2 (PBX2) TALE/PBX homeobox family P40425

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625